A long noncoding RNA helps improve gum disease.
A Long Noncoding RNA Amerliorates Periodontitis via Distinct Epigenetic Pathways
This study is looking at how a special type of RNA called ANRIL can help treat gum disease by reducing inflammation and helping your gums heal, with the hope of finding better and safer treatments for people affected by this common condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10979179 on NIH RePORTER |
What this research studies
This research investigates the role of long noncoding RNAs in treating periodontal disease, which affects nearly half of adults over 30 in the U.S. The study focuses on understanding how a specific long noncoding RNA, ANRIL, can reduce inflammation and promote bone regeneration in the gums. By using advanced techniques to manipulate this RNA, researchers aim to find a more effective and safer treatment for periodontal disease. The findings could lead to new therapies that not only address gum health but also improve overall systemic health affected by periodontal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 30 who are experiencing periodontal disease.
Not a fit: Patients under 30 years old or those without periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that effectively cure periodontal disease and reduce its associated health risks.
How similar studies have performed: Other research has shown promising results in using long noncoding RNAs for various diseases, suggesting potential success in this novel application for periodontal disease.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Jake Jinkun — Tufts University Boston
- Study coordinator: Chen, Jake Jinkun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.