Sponsor or institution
Clinical trials and research at Tufts University Boston
As of November 12, 2026, Find a Trial lists 246 NIH-funded research projects at this institution, with $157.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 246NIH research projects
NIH-funded research (newest 40 of 246)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Diagnostics Core for Lyme disease testing and sample archiving
A centralized diagnostics core at a CLIA-certified lab provides standard Lyme disease tests and sample handling to support patient studies.
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Clinical Coordination Core for Lyme disease and tickborne infections
A patient-facing core is coordinating care and enrollment for people with early Lyme disease and for antibody-based studies among groups at high risk of tick exposure.
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Understanding why some people have ongoing symptoms after Lyme disease
A long-term study follows people diagnosed with acute Lyme disease to see who develops persistent symptoms and why, with care from a team of Lyme experts.
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How bacteria talk to each other and what that means for infections
Researchers are studying how bacteria communicate and adapt in crowded environments like infections, with the goal of understanding what makes some bacteria more harmful or harder to treat.
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Transdiagnostic therapy to improve mental health and TB treatment outcomes in India
A doctor-research team will test a flexible mental health therapy called CETA to help people with tuberculosis who also struggle with depression and unhealthy alcohol use, aiming to improve their TB treatment success.
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Precision nutrition for personalized health in All of Us New England
A patient-focused program will study how different diets affect health in adults in the All of Us community, using real-world meals and controlled feeding sessions.
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Helping cells keep proteins properly folded in the endoplasmic reticulum
This project identifies how cells prevent proteins from misfolding in the ER to help people with diseases like cystic fibrosis and some neurodegenerative conditions.
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Integrating urine isoniazid testing into routine TB care to spot nonadherence
A clinician-facing test using urine isoniazid at regular TB clinic visits helps detect whether people are taking their TB medicines, with the aim of preventing death, recurrence, and drug resistance.
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Single-cell analysis of antibiotic-tolerant subpopulations in Acinetobacter baumannii
Researchers are studying tiny subgroups of the hospital bacteria Acinetobacter baumannii to understand why some cells survive antibiotics and how resistance develops, with potential to improve treatments.
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GSK3 inhibitor therapy to correct CTNNB1 syndrome in patient-derived neurons
A small molecule drug that targets GSK3 could help correct brain cell problems in people with CTNNB1 syndrome.
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Canine cancer model to detect early treatment failure and guide therapy in pediatric bone cancer
A dog model of osteosarcoma is being used to spot relapse early and test treatment changes so children with bone cancer may get better, faster.
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Oral Microbiome Foundation Model to Predict Alzheimer’s Disease
A physician-scientist team will build a large, chatty AI model based on oral microbiome data to help predict Alzheimer’s disease in people, using information from saliva and related samples.
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Food-based nutrition program to improve pregnancies outcomes
A large clinical trial will test if providing medically tailored groceries and nutrition education during pregnancy can reduce adverse pregnancy outcomes for pregnant people.
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Let-7 MicroRNA Link Between Adolescent Opioid Exposure and Future Opioid Use in Rats and Humans
This grant studies how opioid use during adolescence in males might change sperm and affect kids or future generations, using both rat models and human data.
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Systems biology study of aging in pet dogs
Aging, the biggest risk for many diseases, will be studied in pet dogs by looking at how genes, the microbiome, metabolism, and epigenetics together influence healthy aging.
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Genetics of aging in pet dogs and why it matters for us
Researchers are studying how genetics shape aging in pet dogs to understand why some dogs live longer and stay healthier.
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Caring for aging brains and bodies: insights from dogs to help people stay sharper longer
A long-running study uses companion dogs to understand what keeps aging people cognitively and physically healthy, with findings expected to inform human aging.
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Environmental Exposome in Dogs and Humans for Healthy Aging
A national study using pet dogs to understand how environmental exposures affect aging and bladder cancer risk, with findings that could also inform human health.
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Participant and Sample Management Core for the Dog Aging Project
A national study of tens of thousands of pet dogs aims to collect and manage surveys, medical records, and biospecimens to better understand aging in dogs.
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Data Core for Dog Aging Project data hub
A large data hub is being built to securely collect, organize, and share health, environmental, and genetic information from tens of thousands of aging dogs.
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Dog Aging Project Administrative Core supports a large long-term aging study in dogs
A big, ongoing study in dogs aims to understand aging by collecting data and samples from tens of thousands of pet dogs to improve health in aging dogs and potentially humans.
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The Dog Aging Project: How genes and environment shape healthy aging in pet dogs
A large, long-term study using pet dogs to understand why some dogs stay healthier longer and what factors in their genes and environment influence aging.
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Multiethnic look at DNA methylation and heart health over time
A multiethnic study will follow adults to see how changes in DNA methylation relate to cardiovascular health and risk over several years.
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Cultivating Enterocytozoon bieneusi in the lab and decoding its genome
Researchers will grow Enterocytozoon bieneusi in advanced lab systems and map its genome to understand how it causes disease in people with HIV/AIDS or weakened immune systems.
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Food is Medicine programs to improve diet and reduce cardiometabolic diseases
A health study from Tufts University is testing how adding medically tailored meals and food-based prescriptions within healthcare can improve diet and lower cardiometabolic disease risk.
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Canine osteosarcoma immunity boost from hyperactivated dendritic cells
A study tests a way to spark a strong anti-tumor immune response in dogs with bone cancer using highly activated immune cells.
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Fentanyl Overdose, Anhedonia, and Relapse Risk in Opioid Use Disorder
This NIH grant aims to understand how a fentanyl overdose might cause anhedonia and raise the risk of relapse for people with opioid use disorder.
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Targeting how the cell’s recycling factories change shape to support healthy aging
A study at Tufts University Boston is exploring how organelles called peroxisomes change their shape and function during fasting to support lipid metabolism and healthy aging.
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New vaccine targets to prevent gonorrhea
Aims to identify and test new vaccine antigens from Neisseria gonorrhoeae to help prevent gonorrhea infections.
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urine isoniazid testing at point-of-care to support TB treatment
A simple urine test done at clinics helps identify TB patients who aren’t taking their medicines, so care teams can intervene early to improve outcomes.
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Post-transcriptional regulation of gene expression by microRNAs in kidney transplant rejection
A kidney transplant study looks at small genetic helpers called microRNAs and how they control gene activity during antibody-driven rejection of the transplant.
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Monthly injectable buprenorphine for people with opioid use disorder in Massachusetts
This project offers monthly injectable buprenorphine to people in Massachusetts with opioid use disorder to help them stay on medication and lower overdose risk.
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How C. difficile spores sense and respond to germinants to start infection
Scientists are studying how C. difficile spores recognize bile acids and amino acids so they can begin causing disease, with implications for preventing infections.
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Metabolomics clocks: a new way to study aging mechanisms
A patient-facing look at how tiny molecules in the body could help us understand why aging happens and how it links to health and disease.
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Modeling clonal blood cell changes in dogs during cancer treatment
This grant studies how spontaneous clonal hematopoiesis can develop in dogs undergoing cancer therapy and what that might mean for future care.
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CNS Exosomes and Adaptive Immunity in Alzheimer’s Disease
This project studies how tiny brain vesicles called exosomes may activate the body's immune system in Alzheimer’s disease, with the goal of understanding mechanisms that could lead to new treatments.
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Trauma, sperm miRNA, and risk to offspring health
A small study will look at how a father's trauma exposure might change his sperm RNA and potentially affect children’s risk for anxiety or behavior changes.
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Community-driven program to grow and use more fruits and vegetables in the Mississippi Delta
A community-engaged program in the Mississippi Delta aims to boost access to fresh produce and use food as medicine to improve health in Black adults.
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Urban rat exposure and pediatric asthma in inner-city children
This grant explores whether living near rats affects how bad asthma is for children in urban areas.
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Microbiology of Post-Treatment Lyme Disease Syndrome in Lyme Arthritis
This project looks at how different strains of the bacteria that cause Lyme disease might influence lingering symptoms after treatment in people with Lyme arthritis.
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