Condition

Waldenstrom Macroglobulinemia clinical trials and research

• 20Clinical trials
• 17Countries

Newest Waldenstrom Macroglobulinemia clinical trials

All recruiting trials (20)

• Pirtobrutinib combined with venetoclax and rituximab for Waldenström's macroglobulinemia

  This treatment tries combining pirtobrutinib, venetoclax, and rituximab in people newly diagnosed with Waldenström's macroglobulinemia (WM)/lymphoplasmacytic lymphoma to see if it controls the disease.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Boston, Massachusetts and 8 other locations · NCT07231952

• New therapy dose test for people with prior B-cell cancers

  This early-phase study tests different doses of LY4152199 to see if it is safe and effective for people who have already been treated for certain B-cell lymphomas.

  Recruiting at 25 sites Phase 1 Eli Lilly and Company · Duarte, California and 50 other locations · NCT07101328

• Personalized exercise and nutrition program to reduce cancer-related fatigue

  This program will try a personalized exercise and diet plan to reduce fatigue for adults with indolent lymphomas (including CLL/SLL and follicular lymphoma).

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06860880

• Zanubrutinib with bendamustine and rituximab for untreated Waldenström macroglobulinemia

  This treatment will try zanubrutinib together with bendamustine and rituximab to see if it produces deep responses in people with untreated Waldenström macroglobulinemia.

  Recruiting at 5 sites Phase 2 Massachusetts General Hospital · Denver, Colorado and 4 other locations · NCT06561347

• Treatment for relapsed or refractory B-cell lymphoma using SynKIR-310

  This study is testing a new treatment called SynKIR-310 to see if it can help adults with relapsed or refractory B-cell lymphoma feel better.

  Recruiting at 5 sites Phase 1 Verismo Therapeutics · Denver, Colorado and 4 other locations · NCT06544265

• Using epcoritamab to treat previously treated Waldenstrom Macroglobulinemia

  This study is testing if a new treatment called epcoritamab can help people with Waldenstrom Macroglobulinemia who have already received other treatments.

  Recruiting at 3 sites Phase 2 Beth Israel Deaconess Medical Center · Boston, Massachusetts and 2 other locations · NCT06510491

• Using CAR T cells to treat certain types of B cell lymphomas

  This study is testing a new CAR T cell therapy to see if it can help adults with certain types of B cell lymphomas that haven't improved with other treatments.

  Recruiting Phase 1 Stanford University · Palo Alto, California · NCT06340737

• Evaluating blood pressure management in patients with B-cell cancers on specific treatments

  This study is trying to see how blood pressure changes in people with B-cell cancers who are being treated with a specific type of medication, and what the best ways are to manage any high blood pressure they might develop.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06151730

• Evaluating zanubrutinib for treating Waldenström Macroglobulinemia

  This study is testing how well zanubrutinib works and how safe it is for people with Waldenström macroglobulinemia, especially those with certain genetic traits and from different backgrounds.

  Recruiting at 6 sites BeOne Medicines · Huntsville, Alabama and 7 other locations · NCT05640102

• Oral AS-1763 treatment for patients with certain blood cancers

  This study is testing a new oral medication called AS-1763 to see if it can help patients with certain blood cancers who haven't had success with other treatments.

  Recruiting at 13 sites Phase 1 Carna Biosciences, Inc. · Orange, California and 12 other locations · NCT05602363

• Evaluating SGR-1505 for treating mature B-cell neoplasms

  This study is testing a new oral medication called SGR-1505 to see if it is safe and effective for people with certain types of B-cell lymphomas that have not responded to other treatments.

  Recruiting at 36 sites Phase 1 Schrödinger, Inc. · Gilbert, Arizona and 35 other locations · NCT05544019

• Combining Venetoclax and Rituximab for treating Waldenström's Macroglobulinemia

  This study is testing whether combining two medications, Venetoclax and Rituximab, can provide a better treatment option for older patients with Waldenström's Macroglobulinemia who haven't had treatment before.

  Recruiting at 12 sites Phase 2 University of Ulm · Bielefeld and 13 other locations · NCT05099471

• Spanish registry of adults with IgM monoclonal gammopathies including Waldenström macroglobulinemia

  This registry collects health, disease, and treatment history from adults in Spain with IgM monoclonal gammopathies, including Waldenström macroglobulinemia, to see which treatments lead to better long-term outcomes.

  Recruiting at 51 sites Fundación Española de Hematología y Hemoterapía · Mérida, Badajoz and 50 other locations · NCT05093153

• Identifying diagnostic criteria for hyperviscosity syndrome in Waldenström Macroglobulinemia

  This study is trying to create better guidelines to diagnose hyperviscosity syndrome in people with Waldenström Macroglobulinemia by looking at both their symptoms and test results.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04898647

• Measuring circulating tumor DNA to predict outcomes after six months of treatment in Waldenström macroglobulinemia

  This will test whether measuring circulating tumor DNA after six months of treatment helps predict outcomes for people with Waldenström macroglobulinemia.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04893564

• Comparing venetoclax and rituximab to ibrutinib and rituximab for treating Waldenstrom's macroglobulinemia

  This study is testing whether a new combination of venetoclax and rituximab works better than the standard treatment of ibrutinib and rituximab for people with Waldenstrom's macroglobulinemia who haven't been treated before.

  Recruiting at 106 sites Phase 2 National Cancer Institute (NCI) · Tucson, Arizona and 149 other locations · NCT04840602

• Oral treatment with LP-168 for patients with certain blood cancers

  This study is testing an oral treatment called LP-168 to see if it can help adults with certain types of blood cancers that have come back or didn't respond to other treatments.

  Recruiting at 4 sites Phase 1 Newave Pharmaceutical Inc · Durham, North Carolina and 3 other locations · NCT04775745

• Comparing two treatment approaches for Waldenström's macroglobulinaemia

  This study is testing a new treatment without chemotherapy for people with Waldenström's macroglobulinaemia to see if it works better and is easier on the body than the standard treatment.

  Recruiting at 25 sites Phase 2/3 University College, London · Bath and 24 other locations · NCT04061512

• Assessing molecular changes in blood cancers

  This study is trying to see how changes in blood samples from people with early blood cancers can help us understand their condition better and find new treatment options.

  Recruiting at 7 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 6 other locations · NCT02269592

• Observing the natural history of certain blood cancers

  This study is tracking how certain blood cancers develop over time in patients to learn more about them and find new treatment options.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00923507

Related topics

Quick answers

How many Waldenstrom Macroglobulinemia clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (15 trials), France (4 trials), Spain (3 trials), Italy (2 trials), Poland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 6, Phase 2: 5, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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