Evaluating SGR-1505 for treating mature B-cell neoplasms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and tolerability of SGR-1505, an oral inhibitor of MALT1, in patients with relapsed or refractory B-cell lymphomas. It aims to determine the maximum tolerated dose (MTD) and assess pharmacokinetics (PK) and pharmacodynamics (PD) of the drug. Additionally, exploratory cohorts will investigate preliminary anti-tumor activity and safety, with plans to evaluate SGR-1505 in combination with other anti-cancer agents for specific B-cell malignancies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy.
* Subject must have measurable or detectable disease according to the applicable disease-specific classification system and meet criteria for initiation of treatment.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Life expectancy ≥ 12 weeks.

Exclusion Criteria:

* The subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit).
* Subject has previous invasive malignancy in the last 2 years.
* Subject has a known allergy to SGR-1505 or excipients of SGR-1505.
* Subject has symptomatic or active CNS involvement of disease.
* Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that would place the participant at increased risk to the use of an investigational drug.

Where it's running

• Banner Health - MD Anderson Cancer Center
  Gilbert, Arizona, United States Recruiting
• Christiana Care Hospital - Helen F Graham Cancer Center
  Newark, Delaware, United States Recruiting
• Napa Research
  Pompano Beach, Florida, United States Recruiting
• Beth Israel Deaconess Medical Center
  Boston, Massachusetts, United States Recruiting
• Regional Cancer Care Associates
  Hackensack, New Jersey, United States Recruiting
• Roswell Park Comprehensive Cancer Center
  Buffalo, New York, United States Recruiting

Study contacts

• Study coordinator: Study Physician
• Email: sdgr-trials-group@schrodinger.com
• Phone: +1 (503)-922-0158

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.