Condition

High-grade B-cell Lymphoma clinical trials and research

• 25Clinical trials
• 1New in 30 days
• 12Countries

Newest High-grade B-cell Lymphoma clinical trials

All recruiting trials (25)

• ctDNA testing in newly diagnosed DLBCL or HGBL to predict treatment outcomes

  This study checks if measuring circulating tumor DNA in blood after first-line therapy can predict whether the disease will stay away or come back in people with DLBCL or HGBL.

  Recruiting at 2 sites Peking University People's Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07878351

• Non-Hodgkin Lymphoma Sample Collection for MRD Testing

  This study tests a blood-based and tissue-based approach to see if a molecular residual disease test can detect lingering cancer in adults with aggressive NHL who are starting standard therapy.

  Recruiting Natera, Inc. · Austin, Texas · NCT07750886

• UB-VV400 with rapamycin in relapsed/refractory B-cell lymphomas

  A phase 1/2 trial tests UB-VV400 plus rapamycin in adults with relapsed or refractory B-cell lymphomas to see if it is safe and shows anti-tumor activity.

  Recruiting at 2 sites Phase 1/2 Umoja Biopharma · Irvine, California and 1 other locations · NCT07735533

• Rituximab and Tafasitamab with Allogeneic NK Cells for relapsed or refractory B-cell NHL

  This trial tests whether giving allogeneic NK cells with Rituximab, Tafasitamab, and IL-2 can help people with relapsed or refractory B-cell non-Hodgkin lymphoma who have tried at least two prior therapies.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT07225439

• Comparing advanced and classical immunotherapy for lymphoma treatment

  This study is testing whether newer immunotherapy treatments for high-grade B cell lymphoma work better and are safer than traditional methods for adults who have already had treatment that didn't work.

  Recruiting at 2 sites Seoul St. Mary's Hospital · Seoul and 1 other locations · NCT06796517

• Treatment for Diffuse Large B-cell Lymphoma using Glofitamab

  This study is testing a new combination of treatments for people with diffuse large B-cell lymphoma to see if it works better and has fewer side effects than current options.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06765317

• Testing blood for cancer DNA in patients with B-cell lymphoma

  This study is testing if a blood test for cancer DNA can help identify patients with B-cell lymphoma who are at risk of having their cancer come back in the brain or spinal cord, even when other tests show no signs of it.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06736613

• Optimizing therapy for newly diagnosed diffuse large B-cell lymphoma using ctDNA

  This study is testing if measuring tumor DNA in the blood during treatment can help people with newly diagnosed diffuse large B-cell lymphoma get less chemotherapy if their cancer shows no signs of activity.

  Recruiting Columbia University · New York, New York · NCT06693830

• How MYC gene changes relate to the tumor immune environment in diffuse large B‑cell and high‑grade B‑cell lymphoma

  This project will see if MYC gene changes and the tumor's immune environment are linked in adults (18–79) who received curative treatment for diffuse large B‑cell or high‑grade B‑cell lymphoma.

  Recruiting at 14 sites Fondazione Italiana Linfomi - ETS · Alessandria and 19 other locations · NCT06588205

• Preventing CAR-T cell toxicities with emapalumab

  This study is testing if a drug called emapalumab can help prevent side effects in people with large B-cell non-Hodgkin's lymphoma who are receiving another treatment called axicabtagene ciloleucel.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06550141

• Treatment for relapsed or refractory B-cell lymphoma using SynKIR-310

  This study is testing a new treatment called SynKIR-310 to see if it can help adults with relapsed or refractory B-cell lymphoma feel better.

  Recruiting at 5 sites Phase 1 Verismo Therapeutics · Denver, Colorado and 4 other locations · NCT06544265

• Gene therapy for certain blood cancers

  This study is testing a new gene therapy called VNX-101 to see if it can help people with certain types of blood cancers that haven't responded to other treatments.

  Recruiting at 11 sites Phase 1/2 Vironexis Biotherapeutics Inc. · Duarte, California and 10 other locations · NCT06533579

• Epcoritamab treatment for certain types of lymphoma

  This study is testing if adding a new treatment called epcoritamab to CAR T cell therapy can help people with certain types of lymphoma who haven't fully responded to previous treatments.

  Recruiting Phase 2 Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06458439

• T-Cell Therapy for Adults with Relapsed B-Cell Non-Hodgkin's Lymphoma

  This study is testing a new T-cell therapy to see if it can help adults with relapsed B-cell non-Hodgkin's lymphoma feel better.

  Recruiting at 5 sites Phase 1/2 Estrella Immunopharma, Inc. · Sacramento, California and 4 other locations · NCT06343311

• Combination therapy with Epcoritamab for relapsed aggressive B-cell lymphoma

  This study is testing if adding Epcoritamab to chemotherapy helps people with relapsed aggressive B-cell lymphoma get better before a stem cell transplant and live longer without the disease coming back.

  Recruiting Phase 2 Australasian Leukaemia and Lymphoma Group · Melbourne, Victoria · NCT06287398

• Treatment of untreated high grade B cell lymphoma with mosunetuzumab and chemotherapy

  This study is testing if a new treatment combining mosunetuzumab and chemotherapy can help people with untreated high grade B cell lymphoma feel better and achieve a complete response.

  Recruiting Phase 1/2 OHSU Knight Cancer Institute · Portland, Oregon · NCT06249191

• CLIC-2201 treatment for relapsed B cell cancers

  This study is testing a new CAR-T cell therapy called CLIC-2201 to see if it can help people with relapsed B cell cancers feel better and improve their treatment outcomes.

  Recruiting at 7 sites Phase 1 British Columbia Cancer Agency · Calgary, Alberta and 6 other locations · NCT06208735

• Long-term follow-up for patients treated with zamtocabtagene autoleucel

  This study follows patients who have received a specific CAR T-cell therapy for non-Hodgkin lymphoma to see how they do over time and if there are any long-term side effects.

  Recruiting at 10 sites Miltenyi Biomedicine GmbH · Gilbert, Arizona and 10 other locations · NCT06116110

• Using CD79b-19 CAR T cells to treat Non-Hodgkin Lymphoma

  This study is testing a new treatment using modified immune cells to see if it can help people with relapsed or hard-to-treat Non-Hodgkin Lymphoma.

  Recruiting Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT06026319

• Combining three anti-cancer drugs for treating relapsed or refractory diffuse large B-cell lymphoma

  This study is testing a combination of three cancer drugs to see if they can help people with tough-to-treat diffuse large B-cell lymphoma feel better and respond to treatment.

  Recruiting at 8 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 7 other locations · NCT06015880

• Combining new drugs with standard treatment for relapsed large B-cell lymphoma

  This study is testing a new combination of drugs for people with large B-cell lymphoma that has come back or didn’t get better with earlier treatments to see if it works better than the usual options.

  Recruiting at 99 sites Phase 2 SWOG Cancer Research Network · Tucson, Arizona and 103 other locations · NCT05890352

• Evaluating SGR-1505 for treating mature B-cell neoplasms

  This study is testing a new oral medication called SGR-1505 to see if it is safe and effective for people with certain types of B-cell lymphomas that have not responded to other treatments.

  Recruiting at 36 sites Phase 1 Schrödinger, Inc. · Gilbert, Arizona and 35 other locations · NCT05544019

• Using acalabrutinib to prevent relapse in patients with large B-cell lymphoma

  This study is testing if the drug acalabrutinib can help prevent cancer from coming back in patients with large B-cell lymphoma who are at high risk after treatment.

  Recruiting at 2 sites Phase 1/2 Jonsson Comprehensive Cancer Center · Los Angeles, California and 2 other locations · NCT05256641

• Efficacy and safety of CRC01 for adult patients with large B-cell lymphoma

  This study is testing a new CAR-T therapy called CRC01, combined with other medications, to see if it can help adults with hard-to-treat large B-cell lymphoma feel better.

  Recruiting at 2 sites Phase 1/2 Curocell Inc. · Seoul and 1 other locations · NCT04836507

• CAR-T therapy outcomes and quality of life in older adults with B‑cell lymphoma

  This project will see how CAR‑T therapy affects older adults (age 60+) with relapsed or refractory B‑cell lymphomas, focusing on daily function and quality of life while they receive standard care.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT04300998

Related topics

Quick answers

How many High-grade B-cell Lymphoma clinical trials are recruiting right now?

25, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (19 trials), South Korea (2 trials), Italy (2 trials), Canada (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 6, Phase 1: 6, Phase 2: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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