Condition

Uveal Melanoma clinical trials and research

• 19Clinical trials
• 21NIH research projects
• 1New in 30 days
• 22Countries

Newest Uveal Melanoma clinical trials

All recruiting trials (19)

• High-precision radiosurgery followed by minimally invasive eye-sparing surgery for prominent uveal melanoma

  This study tests a modern, precise radiosurgery approach followed by a minimally invasive surgery to see if it can control the tumor while preserving vision in patients with high-prominence uveal melanoma.

  Recruiting at 3 sites University Hospital, Essen · Essen, Germany / NRW and 2 other locations · NCT07913412

• Adjuvant darovasertib and crizotinib in high-risk non-metastatic uveal melanoma

  Researchers are testing whether adding darovasertib and crizotinib after local eye tumor treatment can help prevent recurrence in people with high-risk, non-metastatic uveal melanoma.

  Recruiting at 4 sites Phase 3 IDEAYA Biosciences · Scottsdale, Arizona and 12 other locations · NCT07804186

• Neoadjuvant immunotherapy for high-risk eye melanoma

  This trial tests whether giving nivolumab and ipilimumab before surgery is safe and feasible for adults with high-risk uveal melanoma.

  Recruiting Phase 1 Herlev Hospital · Herlev, Herlev · NCT07501117

• Immune response after delivering melphalan directly to the liver for uveal (eye) melanoma that has spread to the liver.

  This test will see how the liver's immune system responds when people with uveal melanoma that has spread to the liver receive melphalan delivered directly to the liver through percutaneous hepatic perfusion.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07364474

• Adding IL-2 to tebentafusp to overcome resistance in uveal melanoma

  This trial tests whether giving interleukin‑2 (IL‑2) together with tebentafusp can help people with HLA‑A*02:01 metastatic uveal melanoma who progressed on tebentafusp.

  Recruiting Phase 1/2 St Vincent's Hospital, Sydney · Sydney, New South Wales and 1 other locations · NCT07063875

• Darovasertib before local treatment for primary uveal melanoma

  This trial tests whether giving darovasertib before surgery or radiation helps people with primary non-metastatic uveal melanoma.

  Recruiting at 25 sites Phase 3 IDEAYA Biosciences · Scottsdale, Arizona and 93 other locations · NCT07015190

• Using quisinostat to prevent uveal melanoma from spreading

  This study is testing if a drug called quisinostat can help prevent uveal melanoma from spreading in patients who are at high risk after their initial treatment.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT06932757

• Testing a new drug for advanced solid tumors that express c-Kit

  This study is testing a new drug for people with advanced solid tumors that have a specific marker called c-Kit to see if it is safe and how well it works.

  Recruiting at 4 sites Phase 1 Novelty Nobility, Inc. · Ann Arbor, Michigan and 4 other locations · NCT06805825

• Identifying new genes linked to hereditary uveal melanoma

  This study is trying to find new genes that might make families more likely to get uveal melanoma, a type of eye cancer, to help improve care and monitoring for those affected.

  Recruiting Centre Jean Perrin · Clermont-Ferrand, Puy-de-Dôme · NCT06550674

• Combination treatment for liver metastases from uveal melanoma

  This study is testing a new combination treatment for patients with liver metastases from uveal melanoma to see if adding a special delivery method can help them live longer without their cancer getting worse.

  Recruiting at 3 sites Phase 3 Vastra Gotaland Region · Gothenburg and 5 other locations · NCT06519266

• Using Tebentafusp to prevent recurrence in high-risk ocular melanoma patients

  This study is testing if a new treatment called tebentafusp can help prevent the return of high-risk uveal melanoma in patients after their initial treatment.

  Recruiting at 15 sites Phase 3 European Organisation for Research and Treatment of Cancer - EORTC · Lake Success, New York and 14 other locations · NCT06246149

• Tebentafusp treatment for previously untreated metastatic uveal melanoma

  This study is testing a new treatment called tebentafusp for people with a rare type of eye cancer called metastatic uveal melanoma to see if it can help them.

  Recruiting at 4 sites Phase 2 University of Pittsburgh · Aurora, Colorado and 3 other locations · NCT06070012

• Register for patients with uveal melanoma

  This study is creating a detailed record of patients with uveal melanoma treated at the Medical University of Vienna to better understand the disease and improve care for those affected.

  Recruiting Medical University of Vienna · Vienna · NCT05733728

• Evaluating lifileucel in patients with advanced uveal melanoma and certain sarcomas

  This study is testing a new treatment called lifileucel to see if it can help people with advanced uveal melanoma and certain types of sarcomas feel better.

  Recruiting at 2 sites Phase 1 Memorial Sloan Kettering Cancer Center · Harrison, New York and 1 other locations · NCT05607095

• Using Melatonin to Prevent Metastases in Uveal Melanoma

  This study is testing whether taking Melatonin at night can help people with uveal melanoma avoid or delay the spread of their cancer.

  Recruiting Phase 3 St. Erik Eye Hospital · Stockholm, Stockholm County · NCT05502900

• Understanding BAP1 Hereditary Cancer Risks

  This study is trying to find out how common certain cancers are in people with BAP1 gene mutations to help improve screening and treatment for them and their families.

  Recruiting Ohio State University · Columbus, Ohio · NCT04792463

• Monitoring patients with uveal melanoma for liver metastases

  This study is testing a special follow-up plan with regular liver scans and blood tests for people with uveal melanoma to see if it helps catch liver cancer spread early.

  Recruiting Institut Curie · Paris · NCT04424719

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Evaluating blood tests for diagnosing metastatic uveal melanoma

  This study is testing if blood tests can help find advanced uveal melanoma earlier than regular scans, which could lead to better treatment options for patients.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT01438658

NIH-funded research (21)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting serotonin receptors to boost a cancer cell weakness in uveal melanoma

  A small funding project tests whether blocking the serotonin HTR2B receptor can weaken mutant GNAQ/GNA11-driven uveal melanoma cells to help fight metastatic eye cancer.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11440890

• Dual mRNA therapeutics aimed at liver metastasis from uveal melanoma

  A new approach uses two mRNA-based therapies designed to target liver metastases in adults with uveal melanoma.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11388819

• Improving treatment response in uveal melanoma by targeting Syk with new translational models

  A Mayo Clinic team is exploring whether blocking the Syk protein can make uveal melanoma more responsive to PARP inhibitors in patients who have this eye cancer that often spreads.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11358775

• How uveal melanoma cells send signals that help them spread

  This project follows adults with uveal melanoma and tracks signals in eye fluid and blood to find early signs that the cancer may be spreading.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11343371

• A safe, minimally invasive test to predict uveal melanoma metastasis risk from eye fluid

  A new test using a sample from the eye’s aqueous fluid could predict if uveal melanoma is likely to spread, without needing a risky biopsy.

  NIH research Olmeda Biosciences LLC · San Diego, United States · NIH-11312222

• Targeting stress defenses in eye melanoma that spreads to the liver

  Researchers are working to weaken tumor cells' defenses against oxidative damage so liver metastases from uveal (eye) melanoma in adults become more vulnerable to treatment.

  NIH research Drexel University · Philadelphia, United States · NIH-11298994

• A new test using eye fluid to predict the risk of uveal melanoma spreading

  This study is looking for a gentler way to check if uveal melanoma, a type of eye cancer, might spread by testing proteins in the eye's fluid instead of using painful needle biopsies, helping doctors make better treatment choices while keeping patients safe.

  NIH research Olmeda Biosciences LLC · San Diego, United States · NIH-11264264

• Targeting RasGRP3 and Protein Kinase D in uveal (eye) melanoma

  Looking into whether blocking the proteins RasGRP3 and Protein Kinase D can lead to new treatments for people with uveal (eye) melanoma, especially those whose cancer has spread.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11252175

• Blocking the Gq signaling pathway in uveal (eye) melanoma

  This research looks at drugs and gene-targeting approaches that block the Gq signaling pathway to try to stop uveal (eye) melanoma growth, especially for patients whose tumors have GNAQ or GNA11 changes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11178548

• SOCS1's role in uveal melanoma response to immunotherapy

  This project looks at whether levels of a protein called SOCS1 can predict and help improve immunotherapy response for people with uveal melanoma.

  NIH research University of Texas El Paso · El Paso, United States · NIH-11169852

• New therapies targeting cancer signaling pathways in uveal melanoma

  This study is looking at how certain changes in proteins related to eye cancer, specifically uveal melanoma, can help us find new ways to treat it, especially for patients whose cancer has spread.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11095748

• Understanding how liver conditions affect uveal melanoma spread

  This study is looking at how uveal melanoma, a serious eye cancer that can spread to the liver, grows in that environment, with the hope of finding new treatments to help patients live longer and better.

  NIH research Drexel University · Philadelphia, United States · NIH-11061803

• Targeting RasGRP3 and Protein Kinase D to treat Uveal Melanoma

  This study is looking for new treatments for uveal melanoma, a serious eye cancer, by exploring how a protein called RasGRP3 affects the disease, with the hope of finding better options for patients like you.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11009582

• Creating a new test to predict the risk of uveal melanoma spreading

  This study is looking for a gentler way to check if uveal melanoma, a type of eye cancer, might spread by testing proteins in the eye's fluid instead of using painful needle biopsies, making it easier for patients to get the information they need for their treatment.

  NIH research Olmeda Biosciences LLC · San Diego, United States · NIH-11006367

• Targeting a specific pathway in uveal melanoma treatment

  This study is looking at a common type of eye cancer called uveal melanoma, which can spread to the liver, and aims to find new ways to stop the cancer from growing and spreading by targeting a specific pathway in the cells, using advanced techniques to help improve treatment options for patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10916279

• Understanding how SOCS1 affects uveal melanoma treatment with immunotherapy

  This study is looking at how a protein called SOCS1 affects how well uveal melanoma patients respond to immunotherapy, with the hope of finding better ways to treat this tough cancer by understanding why current treatments aren't working as well as they should.

  NIH research University of Texas El Paso · El Paso, United States · NIH-10897221

• Understanding and targeting the genetic changes in uveal melanoma that lead to liver metastasis

  This study is looking at how certain changes in genes and cells in uveal melanoma, a serious eye cancer, can lead to it spreading to the liver, and it hopes to find new treatments that could help high-risk patients manage this spread better.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-10894641

• Investigating how ASAP1 affects the spread of uveal melanoma

  This study is looking at how a protein called ASAP1 affects the spread of uveal melanoma, a type of eye cancer, to find new ways to help prevent or treat it for patients.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10891549

• Investigating a new treatment for uveal melanoma using a specific drug.

  This study is testing a new drug called 64B to see if it can help treat advanced eye cancer, specifically metastatic and high-risk uveal melanoma, by working alongside other treatments to slow down tumor growth and improve survival, making it a hopeful option for patients facing this condition.

  NIH research Oncospherix, INC. · Atlanta, United States · NIH-10817841

• Combining a vaccine and T cell therapy to treat uveal melanoma

  This study is testing a new way to treat metastatic uveal melanoma by using a special vaccine and a personalized T cell therapy to help your immune system fight the cancer better.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10669241

• Using small molecule drugs to improve CAR T cell therapy for Uveal Melanoma

  This study is looking at a new way to make CAR T cell therapy work better for people with Uveal Melanoma, a rare eye cancer that can spread to the liver, by using special medicines to shrink tumors and boost the immune system's ability to fight them.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10652851

Related topics

Quick answers

How many Uveal Melanoma clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (10 trials), France (4 trials), Sweden (3 trials), Germany (3 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 1: 4, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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