Understanding and targeting the genetic changes in uveal melanoma that lead to liver metastasis
Characterization and targeting of the epigenetic state underlying uveal melanoma liver metastasis
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-10894641
This study is looking at how certain changes in genes and cells in uveal melanoma, a serious eye cancer, can lead to it spreading to the liver, and it hopes to find new treatments that could help high-risk patients manage this spread better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10894641 on ClinicalTrials.gov |
What this research studies
This research focuses on uveal melanoma, a serious eye cancer that can spread to the liver. It aims to identify the genetic and molecular changes that contribute to this spread, particularly in high-risk patients. By studying the role of specific mutations and cellular behaviors, the research seeks to uncover potential new treatments that could prevent or manage liver metastases. Patients may benefit from insights that could lead to more effective therapies tailored to their specific cancer characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with uveal melanoma, especially those classified as high-risk due to specific genetic mutations.
Not a fit: Patients with low-risk uveal melanoma or those whose cancer has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with uveal melanoma, particularly those at high risk for liver metastasis.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors of uveal melanoma, but this specific approach to targeting liver metastasis is relatively novel.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMALLEY, KEIRAN — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: SMALLEY, KEIRAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.