Condition

Upper Tract Urothelial Carcinoma clinical trials and research

• 13Clinical trials
• 2NIH research projects
• 1New in 30 days
• 5Countries

Newest Upper Tract Urothelial Carcinoma clinical trials

All recruiting trials (13)

• Urinary Cell-Free DNA Test for Urothelial Cancer Origin

  This study tests a urine-based cell-free DNA test to help diagnose urothelial cancer and identify whether it started in the bladder or upper urinary tract in adults.

  Recruiting Ruijin Hospital · Shanghai · NCT07888374

• Blood test for detecting tumor DNA in bladder and upper tract cancer

  A blood test that looks for tumor DNA in people with muscle-invasive bladder cancer or upper tract urothelial cancer is being tested to see if it matches what’s found in tumor tissue and if it can help track recurrence or remission over two years.

  Recruiting AZ Sint-Lucas Gent · Ghent, East Flanders · NCT07756437

• Non-invasive urine test to screen for urothelial cancer in adults with blood in urine

  A noninvasive urine test is being used to see if it can correctly identify urothelial cancer in adults who have blood in urine and a suspicious imaging finding.

  Recruiting Henan Provincial People's Hospital · Zhengzhou, Henan · NCT07614594

• Flexible ureteroscopy to monitor upper tract urothelial carcinoma

  A small, forward-looking study will test whether doing flexible ureteroscopy under local anesthesia is safe and feasible for people who have had kidney-sparing treatment for upper tract urothelial carcinoma.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07557563

• Disitamab Vedotin Plus Radiotherapy for HER2-Expressing Upper Tract Urothelial Carcinoma After Surgery

  This study tests whether disitamab vedotin with radiotherapy can improve outcomes for people with HER2-expressing upper tract urothelial carcinoma after radical surgery who can’t receive cisplatin.

  Recruiting Phase 3 Peking University First Hospital · Beijing · NCT07498907

• Dual-target Nectin-4 and HER2 CAR-NK therapy for advanced urothelial carcinoma

  This treatment will try dual-target CAR-NK cells that recognize Nectin‑4 and HER2 in adults with relapsed or metastatic urothelial carcinoma after standard therapies.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07492628

• Kidney-and-ureter removal with or without template lymph node removal for high-risk upper tract urothelial cancer

  This trial will test whether adding a template lymph node removal to standard kidney-and-ureter surgery helps people with high-risk upper tract urothelial cancer live longer without the cancer coming back.

  Recruiting Tianjin Medical University Second Hospital · Tianjin, Tianjin Municipality · NCT07321210

• Cisplatin chemotherapy followed by maintenance avelumab for upper tract urothelial carcinoma

  This trial will try maintenance avelumab after adjuvant cisplatin chemotherapy to see if it reduces recurrence in adults with high-risk, surgically removed upper tract urothelial carcinoma who are disease‑free after chemo.

  Recruiting Phase 2 Samsung Medical Center · Seoul, Gangnam · NCT07225374

• Neoadjuvant tislelizumab plus nab‑paclitaxel before radical nephroureterectomy for upper tract urothelial carcinoma

  This will test whether giving the PD‑1 drug tislelizumab together with nab‑paclitaxel before surgery helps people with non‑metastatic upper tract urothelial carcinoma.

  Recruiting Phase 2 Tianjin Medical University Second Hospital · Tianjin, Outside U.S. · NCT07126119

• Fluorescence detection of upper tract urothelial carcinoma with oral 5-ALA during ureteroscopy

  This study tests whether taking oral 5-ALA before ureteroscopy helps surgeons use blue-light fluorescence to see and remove upper tract urothelial tumors in adults having ureteroscopic tumor resection.

  Recruiting Phase 2 Henry Ford Health System · Detroit, Michigan · NCT06948552

• Ambulatory flexible ureteroscopy under local anaesthesia for UTUC surveillance

  This pilot will try flexible ureteroscopy under local anaesthesia to see if it is safe and workable for people needing surveillance after kidney-sparing surgery for upper tract urothelial carcinoma.

  Recruiting Phase 1 Chinese University of Hong Kong · Hong Kong and 1 other locations · NCT06848868

• Home-based exercise program to improve physical function for bladder cancer patients

  This study is testing whether a home-based exercise program can help bladder cancer patients recover better and improve their physical health before and after surgery.

  Recruiting University of Washington · Seattle, Washington · NCT06040762

• Combination treatment for HER2-positive upper tract urothelial carcinoma after surgery

  This study is testing a new combination of targeted therapy and immune treatment to see if it helps prevent cancer from coming back in patients with HER2-positive upper tract urothelial carcinoma after surgery.

  Recruiting Phase 2 Jinling Hospital, China · Nanjing, Jiangsu · NCT05917158

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improved 3D guidance for kidney-sparing endoscopic UTUC treatment

  A Vanderbilt team is testing a new 3D-guided approach to precisely locate and treat upper tract urothelial cancer during kidney-sparing endoscopic procedures.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11366209

• Identifying DNA changes to improve diagnosis and prognosis of upper tract urothelial carcinoma

  This study is looking at how changes in DNA from urine samples can help doctors better diagnose and understand the risks of upper tract urothelial carcinoma (UTUC) before surgery, making it easier for patients to get the right treatment.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11044045

Related topics

Quick answers

How many Upper Tract Urothelial Carcinoma clinical trials are recruiting right now?

13, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (7 trials), Hong Kong (2 trials), United States (2 trials), South Korea (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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