Cisplatin chemotherapy followed by maintenance avelumab for upper tract urothelial carcinoma

A Prospective Phase II Study of Adjuvant Cisplatin-Based Chemotherapy Followed by Maintenance Avelumab in Upper Tract Urothelial Carcinoma

This trial will try maintenance avelumab after adjuvant cisplatin chemotherapy to see if it reduces recurrence in adults with high-risk, surgically removed upper tract urothelial carcinoma who are disease‑free after chemo.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 48 (estimated)
• Ages: 20 Years and up
• Sex: All
• Sponsor: Samsung Medical Center (other)
• Drugs / interventions: avelumab, chemotherapy, prednisone, Nivolumab
• Locations: 1 site (Seoul, Gangnam)
• Trial ID: NCT07225374 on ClinicalTrials.gov

What this trial studies

This prospective Phase II trial enrolls adults with high-risk upper tract urothelial carcinoma (renal pelvis or ureter) who have undergone curative surgery and completed 3–4 cycles of adjuvant cisplatin-based chemotherapy with no evidence of disease. Enrolled participants will receive maintenance avelumab (10 mg/kg) and undergo scheduled screening, imaging, urine cytology, cystoscopy, best supportive care, and follow-up visits. The study measures whether adding maintenance immunotherapy after standard adjuvant chemotherapy prolongs disease-free intervals compared with historical expectations. Eligibility requires ECOG 0–1 and adequate hematologic and renal function prior to starting maintenance therapy.

Who should consider this trial

Good fit: Adults (≥19 years) with histologically proven high-risk muscle-invasive or node-positive UTUC of the renal pelvis or ureter who have ECOG 0–1, completed at least 3–4 cycles of adjuvant cisplatin-based chemotherapy, show no evidence of disease on imaging/cytology/cystoscopy, are ≥3 weeks from surgery/chemotherapy, and have adequate blood counts and renal function are ideal candidates.

Not a fit: Patients with non–muscle-invasive disease, persistent or recurrent disease after chemotherapy, inability to receive cisplatin, poor performance status, or significant organ dysfunction are unlikely to benefit from this maintenance approach.

Why it matters

Potential benefit: If successful, maintenance avelumab could lower recurrence rates and extend disease-free survival after surgery and adjuvant cisplatin chemotherapy.

How similar studies have performed: Maintenance avelumab improved overall survival after first-line chemotherapy in metastatic urothelial carcinoma (JAVELIN Bladder 100), but adjuvant benefit in resected UTUC is not yet proven and prior adjuvant nivolumab did not show improved DFS for UTUC.

Eligibility criteria

Inclusion Criteria:

* Must be aged 19 years or more
* Must have histologically or cytologically proven UTUC arising from renal pelvis and/or ureter.
* Must have histological evidence of high-risk muscle-invasive disease (i.e., pT2\~ T4) and/or N+ disease.
* Must have an ECOG performance status of 0 to 1
* Received at least 3 or 4 cycles of adjuvant cisplatin-based chemotherapy, and proved to have no evidence of disease recurrence with imaging studies, urine cytology and cystoscopy
* At least 3 weeks since the last surgical procedures or chemotherapy prior to enrolment. Subjects must have recovered to \<Grade 2 from all acute toxicities or toxicity must be deemed irreversible by the investigator.
* Adequate marrow function without growth factor support or transfusion dependency A. Neutrophil 1,500 cells/μL or more B. Platelet count 100,000/μL or more C. Hemoglobin 9.0 g/dL or more
* Adequate renal function with serum creatinine 1.5 x ULN or a calculated creatinine clearance ≥ 50 mL/min using the CockcroftGault or MDRD formulas
* Adequate hepatic function A. Bilirubin 1.5 times upper limit of normal (x ULN) or less; does not apply to subjects with Gilbert's syndrome diagnosed as per institutional guidelines. B. AST (SGOT) and ALT (SGPT) 3 x ULN or less; if liver metastases are present, then 5 x ULN is allowed.
* Women of childbearing potential must use effective contraception continuously for at least 30 days after the final dose of avelumab. At least one method classified as "highly effective" (failure rate \< 1%) must be employed (see Table 1).
* Written and voluntary informed consent understood, signed and dated.
* Negative serum or urine pregnancy test at screening for women of childbearing potential.

Exclusion Criteria

* Ongoing treatment with an anticancer agent not contemplated in this protocol
* Radiologic finding consistent with metastatic disease
* Severe medical or psychological illness that preclude participation to study, including any history of clinically relevant coronary artery disease or myocardial infarction within the last 3 years, New York Heart Association (NYHA) grade III or greater congestive heart failure, cerebrovascular attack within the prior year, or current serious cardiac arrhythmia requiring medication except atrial fibrillation
* Non-tolerable \> Grade 2 neuropathy or evidence of unstable neurological symptoms within 4 weeks of Cycle 1 Day 1
* Major surgery, other than diagnostic surgery or transurethral resection, within 4 weeks prior to Cycle 1 Day 1, without complete recovery
* Double primary cancer of other site(s) or a history of other malignancies, except for cured ones at the discretion of investigator
* Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy.
* Subjects who have exhibited allergic reactions to study treatment.
* Concomitant disease or condition that could interfere with the conduct of the study, or that would, in the opinion of the Investigator, pose an unacceptable risk to the subject in this study.
* Subject with legal incapacity or limited legal capacity. Dementia or significantly altered mental status that would limit the understanding or rendering of informed consent and compliance with the requirements of this protocol. Unwillingness or inability to comply with the study protocol for any reason.
* Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. Systemic corticosteroids at physiologic doses ≤ 10 mg/day of prednisone or equivalent; c. Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication). 12) Active autoimmune disease requiring systemic immunosuppressive treatment. Patients with controlled autoimmune disease not requiring systemic immunosuppressive treatment including diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment are eligible.
* Prior organ transplantation including allogenic stem-cell transplantation.
* Vaccination within 4 weeks of the first dose of avelumab and while on trials is prohibited except for administration of inactivated vaccines.
* Persisting toxicity related to prior therapy (NCI CTCAE Grade \>

  1); however, alopecia, sensory neuropathy Grade ≤ 2, or other Grade ≤ 2 not constituting a safety risk based on investigator's judgment are acceptable.
* Lactating Women Must discontinue breastfeeding during study treatment and for at least 30 days after administration of the final dose of study drug.

Where this trial is running

Seoul, Gangnam

• Samsung Medical Center — Seoul, Gangnam, South Korea (RECRUITING)

Study contacts

• Principal investigator: SE HOON PARK, MD,PhD — SamsungMedicalCenter
• Study coordinator: SE HOON Park, MD,PhD

Conditions: Upper Tract Urothelial Carcinoma