Condition

Locally Advanced Urothelial Carcinoma clinical trials and research

• 6Clinical trials
• 2Countries

Newest Locally Advanced Urothelial Carcinoma clinical trials

All recruiting trials (6)

• Dual-target Nectin-4 and HER2 CAR-NK therapy for advanced urothelial carcinoma

  This treatment will try dual-target CAR-NK cells that recognize Nectin‑4 and HER2 in adults with relapsed or metastatic urothelial carcinoma after standard therapies.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07492628

• Consolidative local surgery for oligo‑metastatic urothelial (bladder) cancer

  This trial will see if adding surgery to remove the bladder tumor (and any resectable metastases) after a good response to enfortumab vedotin–based therapy helps people with locally advanced or oligo‑metastatic urothelial cancer.

  Recruiting Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07048457

• Pembrolizumab plus sacituzumab govitecan versus standard treatments for advanced urothelial cancer

  This trial will test whether adding sacituzumab govitecan to pembrolizumab works better than standard chemotherapy options for adults with locally advanced or metastatic urothelial cancer who have progressed after prior therapy.

  Recruiting at 161 sites Phase 3 National Cancer Institute (NCI) · Phoenix, Arizona and 162 other locations · NCT06524544

• Comparing home and clinic administration of nivolumab for cancer treatment

  This study tests whether giving cancer patients their treatment at home instead of in a clinic makes them feel better and prefer their care more.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT06265285

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Combining cabozantinib and enfortumab vedotin for advanced bladder cancer

  This study is testing a new combination of two drugs, cabozantinib and enfortumab vedotin, to see if it can help people with advanced bladder cancer feel better and live longer.

  Recruiting Phase 1 Emory University · Atlanta, Georgia · NCT04878029

Related topics

Quick answers

How many Locally Advanced Urothelial Carcinoma clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (5 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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