Condition

Temporomandibular Disorders (TMD) clinical trials and research

• 17Clinical trials
• 1NIH research projects
• 11Countries

Newest Temporomandibular Disorders (TMD) clinical trials

All recruiting trials (17)

• AI-assisted approach to diagnose and treat temporomandibular disorders

  This study tests a machine-learning approach that uses clinical data, CBCT, and MRI to guide personalized treatment for people with temporomandibular disorders.

  Recruiting En Chu Kong Hospital · New Taipei City, Sanxia · NCT07771296

• Occlusal splint plus Rocabado jaw exercises for temporomandibular disorder

  This project will see if adding daily Rocabado jaw exercises to nightly occlusal splint use helps adults (18-65) with temporomandibular disorder reduce pain, improve jaw movement, and change muscle mechanical properties.

  Recruiting Acibadem University · Istanbul, Tuzla · NCT07507734

• See if the Modjaw digital jaw impressions help diagnose TMJ disc displacement

  This interventional study tests whether Modjaw digital jaw recordings can help diagnose TMJ disc displacement in adults who already need an MRI for confirmation.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT07499869

• Online or group physiotherapy versus one-on-one physiotherapy for jaw (TMD) muscle pain

  This trial will test whether online or group physiotherapy works as well as individual physiotherapy for adults with TMD-related jaw muscle pain.

  Recruiting at 2 sites Semmelweis University · Budapest, Pest County and 1 other locations · NCT07474662

• Occlusal equilibration versus sham therapies for long-term relief of temporomandibular disorder pain — post‑trial follow‑up

  This follow-up tests whether a bite‑adjustment procedure called physiologically oriented occlusal equilibration provides lasting pain relief for adults who previously had chronic TMD and were treated at the University of Santiago de Compostela.

  Recruiting University of Santiago de Compostela · Santiago de Compostela, A Coruña and 1 other locations · NCT07445516

• Virtual planning for total temporomandibular joint replacement

  This project sees if virtual planning using standard (non‑custom) TMJ prostheses can plan jaw and implant positioning for patients who already had total TMJ replacement.

  Recruiting Lund University Hospital · Lund · NCT07373184

• Liquid-phase concentrated growth factor versus arthrocentesis for temporomandibular disc displacement

  This trial will test whether injecting liquid-phase concentrated growth factor into the temporomandibular joint works better than standard arthrocentesis for adults (18–45) with unilateral disc displacement.

  Recruiting Horus University · Damietta, New Damietta · NCT07075276

• Mobile prompts and education to reduce jaw clenching and awake bruxism

  This trial tests whether a one-week mobile prompt program combined with an educational video helps adults with temporomandibular disorder (TMD) or awake bruxism reduce jaw clenching and masticatory muscle activity compared with education alone.

  Recruiting University of Toronto · Toronto, Ontario · NCT07022795

• Using paintings to help people describe and manage jaw (TMJ) pain

  This randomized trial will test whether adding an art-based tool to standard care helps adults with Wilkes stage I–II TMD better describe their pain, improve jaw function, and reduce anxiety.

  Recruiting Phase 3 King Abdulaziz University · Jeddah, Mecca Region · NCT07018791

• Two-week gratitude journaling for temporomandibular (jaw) pain and overlapping chronic pain.

  This study will see if two weeks of gratitude journaling helps adults with TMD and other chronic overlapping pain feel less pain and have less disruption in daily life.

  Recruiting University of Florida · Gainesville, Florida · NCT06977100

• Exploring the link between jaw disorders and sleep issues

  This study is trying to see if people with jaw problems also have sleep issues and how these two conditions might be connected.

  Recruiting IRCCS San Raffaele · Milan, Italy and 1 other locations · NCT06975709

• Self-management program for chronic orofacial pain from temporomandibular disorder.

  This will test whether a self-management program helps adults (18–65) with chronic TMD-related orofacial pain reduce pain and improve function compared with guideline-based care.

  Recruiting Fundación Universidad Católica de Valencia San Vicente Mártir · Valencia, Valencia · NCT06932406

• Arthroscopic lysis and lavage versus operative arthroscopy for TMJ disc displacement with reduction

  This study tests two types of TMJ arthroscopy to see which one better improves mouth opening, reduces pain, and helps daily function in adults with painful disc displacement that reduces.

  Recruiting Karolinska Institutet · Huddinge · NCT06782191

• Arthroscopy versus arthrocentesis for TMJ disc displacement without reduction

  This trial will try two surgical procedures — arthroscopic lysis and lavage versus arthrocentesis — to see which better helps adults with painful TMJ disc displacement that limits mouth opening.

  Recruiting Karolinska Institutet · Huddinge · NCT06782178

• Long-term follow-up after TMJ surgery to see if 6-month results predict outcomes about 10 years later

  This will see if people who had TMJ surgery for disc displacement still have the same results at about 10 years as they did at 6 months, and whether their joint X-rays show more or less degeneration.

  Recruiting Karolinska Institutet · Huddinge · NCT06782165

• Examining jaw function and pain in pregnant women

  This study looks at how pregnancy affects jaw function and pain in women by comparing pregnant and non-pregnant women to see what differences exist.

  Recruiting Karadeniz Technical University · Trabzon · NCT06760884

• Evaluating a new manual therapy for jaw disorders

  This study is testing a new hands-on treatment for people with jaw disorders to see if it helps reduce pain and improve their quality of life compared to a fake treatment.

  Recruiting Karabuk University · Merkez, Karabük Province · NCT06627855

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using voice analysis to detect pain in people with jaw disorders

  This study is looking at how voice analysis can help identify pain in people with jaw issues, and it will test a gentle light treatment to see if it can reduce their pain and swelling, all while finding safe, drug-free ways to help manage their discomfort.

  NIH research University of Florida · Gainesville, United States · NIH-11110658

Related topics

Quick answers

How many Temporomandibular Disorders (TMD) clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in Sweden (4 trials), Turkey (Türkiye) (3 trials), Spain (2 trials), France (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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