Liquid-phase concentrated growth factor versus arthrocentesis for temporomandibular disc displacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized clinical trial compares liquid-phase concentrated growth factor (LPCGF) injections with conventional arthrocentesis in adults aged 18–45 diagnosed with unilateral temporomandibular disc displacement. Eligible participants are ASA I with near-complete natural dentition and Angle Class I occlusion, and will be randomized to receive either LPCGF or standard arthrocentesis with standardized follow-up visits. Outcomes include pain, joint sounds, maximum mouth opening, and safety measures to determine whether LPCGF provides superior symptom relief or functional improvement. The study is conducted at the Faculty of Dentistry, Horus University in Damietta/New Damietta, Egypt, and excludes patients with prior TMJ surgery or systemic conditions that impair healing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Adults aged 18-45 years. 2. Patients scored as (ASA I).9 3. Presence of complete or nearly complete set of natural dentition with Angle class I occlusion. 4. Diagnosed with unilateral involvement of disc displacement, according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD).10 5. Symptoms include one or more of the following: pain, joint sounds, and limited mandibular movement (Maximum Mouth Opening\< 40mm) 6. No prior surgical intervention for TMD. 7. Patient's willingness to participate and follow the study protocol.

Exclusion Criteria:

* 1\. TMJ pathology related to mechanical deformities 2. Psychiatric problems or presence of systemic diseases that may affect healing (e.g., uncontrolled diabetes, autoimmune disorders, hematologic or neurologic disorders, inflammatory or connective tissue disorders as well as rheumatological or previous infectious diseases, head and neck cancer). 3. Patient unwilling or has contraindication to MRI 4. Previous injections or surgical interventions of the TMJ. 5. Concurrent use of anticoagulants or anti-inflammatory medications within the last 30 days. 6. Pregnant or breastfeeding women. 7. History of trauma or infection in the TMJ region. 8. Allergy to local anesthetics or other components used in the study. 9. Patients diagnosed with (Disc Displacement with reduction with no pain or limited mandibular movements).

Where it's running

• Faculty of Dentistry- Horus University in Egypt
  Damietta, New Damietta, Egypt Recruiting

Study contacts

• Principal investigator: Mohamed Ali Habib, Teaching Assistant — Horus University in Egypt - Faculty of dentistry
• Study coordinator: Mohamed Ali Habib, Teaching assistant
• Email: mbasiouny@horus.edu.eg
• Phone: +2001069505336

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.