AI-assisted approach to diagnose and treat temporomandibular disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial combines machine learning with standard clinical assessment and imaging to identify core issues in TMD patients. It enrolls about 180 participants and uses strict screening to exclude psychosocial confounders and certain comorbidities. Baseline CBCT and MRI data, along with clinical exams, train multi-modal models to predict the need for MRI and to tailor treatment. Participants are stratified by maximum mouth opening and randomized to three treatment arms: proprioceptive training with sham laser and low-level laser therapy (LLLT), proprioceptive training with active LLLT, or a waiting-list control receiving standard care. The aim is to improve diagnostic precision and create a predictive framework for imaging necessity and targeted interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with temporomandibular disorders (TMDs) screened by the Department of Dentistry, Division of Oral and Maxillofacial Surgery at En Chu Kong Hospital, who have failed to respond to analgesic treatment for at least one week.
* Patients clinically examined and identified as having pain predominantly originating from muscles associated with mandibular movement.
* Patients aged between 18 and 70 years (inclusive) with full legal capacity.
* Patients who are willing to participate in the study and provide written informed consent.

Exclusion Criteria:

* Patients meeting any of the following clinical scale thresholds: Generalized Anxiety Disorder-7 (GAD-7)≥ 10, Patient Health Questionnaire-9 (PHQ-9) ≥ 15, Patient Health Questionnaire-15 (PHQ-15) ≥ 10, or Pittsburgh Sleep Quality Index (PSQI) \> 5.
* Patients with tumors of the temporomandibular joint (TMJ) or head and neck region.
* Patients with acute or chronic infections.
* Patients with a history of neuropathy or stroke.
* Patients with a history of head and neck trauma.
* Patients diagnosed with fibromyalgia.
* Patients diagnosed with autoimmune or rheumatic diseases.
* Patients diagnosed with irritable bowel syndrome (IBS).
* Patients with claustrophobia (unable to undergo MRI examination).
* Women who are pregnant or lactating, or parents currently in the infant care/nursing period.
* Patients who have received invasive treatment for temporomandibular joint disorders within the past 3 months.

Where it's running

• En Chu Kong Hospital
  New Taipei City, Sanxia, Taiwan Recruiting

Study contacts

• Study coordinator: Ting-Yu Huang, D.D.S.
• Email: tingyuh3012@gmail.com
• Phone: +886-933-605-102

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.