Condition

Richter Syndrome clinical trials and research

• 6Clinical trials
• 3Countries

Newest Richter Syndrome clinical trials

All recruiting trials (6)

• Pirtobrutinib added to R-CHOP for newly diagnosed Richter transformation in Lymphoma

  This trial tests whether adding pirtobrutinib to the standard R-CHOP treatment helps people with Richter transformation (a CLL/SLL that becomes aggressive LBCL).

  Recruiting at 62 sites Phase 3 SWOG Cancer Research Network · Irvine, California and 61 other locations · NCT07220187

• Using Mosunetuzumab with CHOP to treat Richter's Syndrome

  This study is testing if a new treatment combining Mosunetuzumab with CHOP chemotherapy can help people with Richter's Syndrome who haven't had treatment before.

  Recruiting at 9 sites Phase 2 GELLC (Grupo Español de Leucemia Linfocítica Crónica) · Barcelona, Barcelona and 15 other locations · NCT06926205

• Nemtabrutinib plus pembrolizumab for Richter transformation (DLBCL subtype)

  This phase II trial tests whether combining nemtabrutinib and pembrolizumab can shrink tumors and help people whose chronic lymphocytic leukemia has transformed into diffuse large B‑cell lymphoma (Richter transformation).

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06863402

• Zanubrutinib with odronextamab for Richter's transformation

  This phase I test will see if combining zanubrutinib with odronextamab helps adults whose chronic lymphocytic leukemia has transformed into aggressive lymphoma (Richter's transformation).

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06735664

• Treatment for Richter Syndrome using Glofitamab with Rituximab or Obinutuzumab plus CHOP

  This study is testing if a new treatment combining Glofitamab with Rituximab or Obinutuzumab and CHOP chemotherapy can help people with untreated Richter Syndrome feel better.

  Recruiting at 6 sites Phase 2 French Innovative Leukemia Organisation · Amiens and 22 other locations · NCT06186648

• Using stem cell transplant and Polatuzumab Vedotin for treating B-cell lymphomas

  This study is testing if a stem cell transplant followed by a new drug called Polatuzumab Vedotin can help people with different types of B-cell lymphomas feel better.

  Recruiting Phase 1/2 New York Medical College · Valhalla, New York · NCT04491370

Related topics

Quick answers

How many Richter Syndrome clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (4 trials), France (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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