Condition
Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma clinical trials that are recruiting, in United States. By phase: Phase 3 (1), Phase 1 (1), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Pirtobrutinib added to R-CHOP for newly diagnosed Richter transformation in Lymphoma | Phase 3 | Irvine, California and 61 other locations | Recruiting | Oct 23, 2025 |
| Zanubrutinib with odronextamab for Richter's transformation | Phase 1 | Duarte, California | Recruiting | Dec 16, 2024 |
| Combining zanubrutinib and CAR T-cell therapy for treating Richter's syndrome | Phase 2 | New York, New York and 2 other locations | Recruiting | May 24, 2023 |
All recruiting trials (3)
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Pirtobrutinib added to R-CHOP for newly diagnosed Richter transformation in Lymphoma
This trial tests whether adding pirtobrutinib to the standard R-CHOP treatment helps people with Richter transformation (a CLL/SLL that becomes aggressive LBCL).
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Zanubrutinib with odronextamab for Richter's transformation
This phase I test will see if combining zanubrutinib with odronextamab helps adults whose chronic lymphocytic leukemia has transformed into aggressive lymphoma (Richter's transformation).
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Combining zanubrutinib and CAR T-cell therapy for treating Richter's syndrome
This study is testing if combining zanubrutinib with CAR T-cell therapy can help people with Richter's syndrome, which is when chronic lymphocytic leukemia turns into a more aggressive lymphoma.
Related topics
Quick answers
How many Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.