Condition

Restless Leg Syndrome (RLS) clinical trials and research

• 6Clinical trials
• 3Countries

Newest Restless Leg Syndrome (RLS) clinical trials

All recruiting trials (6)

• Crisugabalin for restless legs and variant restless legs

  This phase 1 trial will test whether crisugabalin (40 mg twice daily) can reduce symptoms in adults aged 18–75 with moderate to severe restless legs syndrome or its variants over 12 weeks.

  Recruiting Phase 1 Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT07453862

• Spinal cord stimulator effects on restless legs

  This study will test whether changing spinal cord stimulator settings alters nerve signals and improves symptoms in people with restless leg syndrome and in some people with chronic pain.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07179406

• Peroneal nerve stimulation for restless legs during pregnancy

  This pilot will test whether a wearable TOMAC peroneal nerve stimulator can reduce restless legs symptoms and improve sleep for pregnant people.

  Recruiting Rhode Island Hospital · Providence, Rhode Island and 1 other locations · NCT07144631

• Cannabis oil for restless legs syndrome

  This trial will test whether cannabis oil helps adults with moderate-to-severe restless legs syndrome feel less leg discomfort and sleep better.

  Recruiting at 2 sites Sunnybrook Health Sciences Centre · Toronto, Ontario and 1 other locations · NCT06863740

• Observing gene changes in patients with Restless Legs Syndrome on dopamine treatment

  This study is trying to see how long-term treatment with dopamine medication affects gene changes in people with Restless Legs Syndrome.

  Recruiting HBC Immunology Inc · San Francisco, California · NCT06726785

• Comparing Lemborexant, Zopiclone, and Clonidine for treating insomnia in chronic pain patients

  This study is testing whether Lemborexant, Zopiclone, or Clonidine can help people with chronic pain sleep better and manage their pain.

  Recruiting Salem Anaesthesia Pain Clinic · Surrey, British Columbia · NCT05618002

Related topics

Quick answers

How many Restless Leg Syndrome (RLS) clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (3 trials), Canada (2 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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