Observing gene changes in patients with Restless Legs Syndrome on dopamine treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to observe changes in the expression of dopaminergic genes in nasal swabs from patients with Restless Legs Syndrome (RLS) who are undergoing prolonged treatment with dopamine agonists. Participants will be divided into two groups: those who have not used a dopamine agonist or have been on it for less than one month, and those who have been treated for six months or more. The study will analyze how these treatments affect gene expression, particularly in relation to Augmentation Syndrome, which can occur with long-term dopamine agonist use. The findings may provide valuable insights into the regulation of dopaminergic genes in RLS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to provide Informed Consent
* Clinical diagnosis of Restless Legs Syndrome (RLS)
* On-going Treatment with a dopamine agonist

Exclusion Criteria:

\* Use of any medication that might affect nasal epithelial cell collection with a nasal swab

Where it's running

• Alethios Inc
  San Francisco, California, United States Recruiting

Study contacts

• Study coordinator: Bomi Framroze, PhD
• Email: bomi.framroze@hbcimmunology.com
• Phone: 6502068006

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.