Condition

Patent Foramen Ovale clinical trials and research

• 15Clinical trials
• 8Countries

Newest Patent Foramen Ovale clinical trials

All recruiting trials (15)

• Long-term outcomes after PFO closure at Severance Hospital

  This registry tests how well percutaneous PFO closure works over the long term and what factors predict residual shunt, new atrial fibrillation, or other outcomes in adults who had the procedure.

  Recruiting Yonsei University · Seoul · NCT07724171

• P3 Occluder System for closing a heart opening (PFO) after stroke

  We are testing the P3 Occluder System to see if it safely and effectively closes a patent foramen ovale in adults who had a stroke related to their heart opening.

  Recruiting Recross Cardio, Inc. · Belgrade · NCT07698951

• PFO-Directed Therapy for Migraines: Closing the Hole or Using a Blood Thinner

  This study tests whether closing a patent foramen ovale (PFO) plus 24 weeks of prasugrel works better for long-term migraine relief than prasugrel alone in people whose migraines improve on blood-thinning therapy.

  Recruiting Phase 3 Columbia University · New York, New York · NCT07629635

• Comparing Cocoon vs Amplatzer PFO Occluders in Adults After Stroke or TIA

  This trial tests whether the Cocoon PFO Occluder works as well as the Amplatzer PFO Occluder in adults who had a cryptogenic stroke or TIA and have a PFO requiring closure.

  Recruiting Sahajanand Medical Technologies Limited · Bad Oeynhausen, North Rhine-Westphalia (Nordrhein-Westfalen) · NCT07380490

• Percutaneous repair of the atrial septum using the P3 Occluder System for PFO closure

  This trial tests the P3 Occluder System to close a patent foramen ovale (PFO) in adults 18–65 who have had a stroke that may be linked to their PFO.

  Recruiting at 5 sites Recross Cardio, Inc. · Los Angeles, California and 4 other locations · NCT07172464

• Closing a PFO to improve glymphatic function and migraine symptoms

  This study will see if closing a patent foramen ovale (PFO) improves glymphatic system function and reduces migraine attacks in adults with PFO and migraine.

  Recruiting at 2 sites First Affiliated Hospital Xi'an Jiaotong University · Luoyang, Henan and 1 other locations · NCT07170176

• Follow-up cohort for migraine patients with a heart condition

  This study is testing different treatment options for migraine patients who also have a heart condition called a patent foramen ovale to see what helps them feel better.

  Recruiting Peking University Third Hospital · Beijing · NCT06953622

• Registry of Endovascular Closure of Patent Foramen Ovale in Russia

  This study is looking at how closing a small hole in the heart called a patent foramen ovale (PFO) affects people over 18 who have had unexplained strokes, to see if it can help improve their health.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT06156670

• Evaluating the CeraFlex PFO Closure System for treating Patent Foramen Ovale

  This study is testing the CeraFlex PFO Closure System to see how well it helps people with a heart condition called Patent Foramen Ovale feel better after the procedure.

  Recruiting at 13 sites Lifetech Scientific (Shenzhen) Co., Ltd. · Bremen and 14 other locations · NCT06120270

• Transcatheter closure versus medical therapy for PFO in older adults

  This tests whether closing a patent foramen ovale (PFO) with a catheter plus usual medicines prevents another unexplained (cryptogenic) stroke in people over 60 better than medicines alone.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec and 1 other locations · NCT05907694

• Evaluating Cera™ devices for closing heart openings in stroke patients

  This study is testing a new device to see if it can safely close heart openings in stroke patients and work as well as other options available.

  Recruiting at 7 sites Lifetech Scientific (Shenzhen) Co., Ltd. · Beijing, Beijing Municipality and 13 other locations · NCT05774288

• Testing a new device for closing a heart defect related to stroke

  This study is testing a new device to close a heart defect in patients who have had a stroke to see if it works as well as other approved devices.

  Recruiting at 8 sites Encore Medical Inc. · Little Rock, Arkansas and 7 other locations · NCT05537753

• Comparing PFO closure and anticoagulants for stroke prevention in older patients

  This study is testing whether closing a small hole in the heart combined with certain medications is better than just using medications alone to prevent strokes in older patients who are at high risk.

  Recruiting at 42 sites Phase 3 Assistance Publique - Hôpitaux de Paris · Amiens and 41 other locations · NCT05387954

• Investigating the internal structure of patent foramen ovale related to stroke and migraine

  This study is trying to learn more about the tiny structures of a heart condition called patent foramen ovale (PFO) in people who have had a stroke, a mini-stroke, or migraines, to see if closing it helps and to understand the risks better.

  Recruiting at 2 sites China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 1 other locations · NCT04686253

• Stopping blood thinners after closing a heart defect in young stroke patients

  This study is testing if young stroke patients can safely stop taking blood thinners a year after having a heart defect fixed.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT04475510

Related topics

Quick answers

How many Patent Foramen Ovale clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (4 trials), United States (3 trials), Canada (2 trials), Germany (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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