Condition

OligoProgressive Metastatic Disease clinical trials and research

• 9Clinical trials
• 5Countries

Newest OligoProgressive Metastatic Disease clinical trials

All recruiting trials (9)

• Focused radiotherapy to control a few growing melanoma spots

  This trial tries adding stereotactic or short-course radiotherapy to up to ten extracranial melanoma spots that are starting to grow while patients stay on their current systemic therapy to see if it delays overall disease progression.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07112170

• Targeted radiotherapy to up to three growing prostate cancer spots in castration‑resistant disease

  This trial will try adding targeted radiotherapy to up to three progressing spots to see if it can delay the next systemic treatment and extend disease control in men with oligoprogressive castration‑resistant prostate cancer.

  Recruiting Phase 2 University Medical Center Groningen · Groningen and 1 other locations · NCT07038304

• Stereotactic body radiation versus changing systemic therapy for oligoprogressive castrate-resistant prostate cancer

  This will try stereotactic body radiotherapy (SBRT) to all oligoprogressive spots while patients stay on their current systemic therapy to see if that controls disease better than switching systemic therapy in men with castration-resistant oligoprogressive prostate cancer.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06927635

• Stereotactic radiotherapy for limited progression in ER+/HER2- metastatic breast cancer

  This trial will try stereotactic body radiotherapy (SBRT) to treat 1–3 new resistant extracranial metastases in women with ER+/HER2- metastatic breast cancer on endocrine therapy and/or CDK4/6 inhibitors to see if local treatment lets them stay on their current systemic therapy longer.

  Recruiting at 5 sites Jules Bordet Institute · Brussels and 4 other locations · NCT06925984

• Stereotactic ablative radiotherapy versus single‑fraction palliative radiotherapy for oligoprogressive metastatic cancer

  This trial will test whether stereotactic ablative radiotherapy (SABR) works better than single‑fraction palliative radiotherapy (8 Gy) for people with 1–5 oligoprogressive metastatic lesions to delay the need for next‑line systemic therapy and improve quality of life.

  Recruiting British Columbia Cancer Agency · Surrey, British Columbia · NCT06918951

• Comparing radiotherapy with early switch to second-line therapy for oligoprogressive HCC

  This study is testing whether adding radiotherapy to ongoing treatment helps people with hepatocellular carcinoma who have limited cancer growth, compared to switching to a different treatment sooner.

  Recruiting Phase 3 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT06841172

• Combining radiotherapy with checkpoint inhibition for metastatic kidney cancer

  This study is testing if combining a new type of radiotherapy with an injectable treatment can help patients with advanced kidney cancer whose disease has continued to progress after previous therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06601296

• Using Stereotactic Body Radiotherapy for treating metastatic lung cancer with limited progression

  This study is testing if adding a special type of radiation therapy to standard treatment can help people with advanced lung cancer live longer and feel better after their first round of chemotherapy.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06523673

• Local therapy to control progressive metastatic cancer

  This study is testing if a combination of local treatments, like radiation therapy, can help people with certain types of cancer that are spreading slowly live longer and feel better compared to standard treatments.

  Recruiting Phase 2/3 M.D. Anderson Cancer Center · Houston, Texas · NCT06367972

Related topics

Quick answers

How many OligoProgressive Metastatic Disease clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in Canada (3 trials), China (2 trials), United States (2 trials), Belgium (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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