Condition

Metastatic Renal Cell Carcinoma ( mRCC) clinical trials and research

• 6Clinical trials
• 1New in 30 days
• 8Countries

Newest Metastatic Renal Cell Carcinoma ( mRCC) clinical trials

All recruiting trials (6)

• Lenvatinib and Pembrolizumab With or Without SBRT for Metastatic Kidney Cancer

  This study tests whether adding SBRT to standard lenvatinib plus pembrolizumab helps people with metastatic kidney cancer who have stable disease after initial treatment.

  Recruiting at 8 sites Phase 2 Kidney Cancer Research Bureau · Kazan' and 7 other locations · NCT07928167

• PF-08634404 alone and with other anticancer medicines for adults with advanced kidney cancer.

  This tests whether PF-08634404, given alone or with other cancer medicines, is safe and helps adults with locally advanced or metastatic kidney cancer who have not had prior systemic treatment.

  Recruiting at 157 sites Phase 1/2 Pfizer · Phoenix, Arizona and 182 other locations · NCT07227415

• First-line immune-checkpoint antibody combinations for advanced clear cell kidney cancer

  This trial tests whether combining fianlimab and cemiplimab, with or without ipilimumab, works better than the standard ipilimumab plus nivolumab as first treatment for people with advanced clear cell kidney cancer.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · Washington D.C., District of Columbia and 4 other locations · NCT07188896

• PET/CT-guided treatment break for metastatic kidney cancer with favorable or intermediate IMDC risk

  This trial tries using PET/CT scans to guide temporary treatment breaks for people with metastatic kidney cancer (IMDC favorable or intermediate risk) who have had at least 12 months of combined PD-1/PD-L1 immunotherapy plus a VEGFR TKI and show a metabolic response.

  Recruiting Phase 2 Jinling Hospital, China · Nanjing, Jiangsu · NCT07175480

• Combining radiotherapy with checkpoint inhibition for metastatic kidney cancer

  This study is testing if combining a new type of radiotherapy with an injectable treatment can help patients with advanced kidney cancer whose disease has continued to progress after previous therapies.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06601296

• Collecting global experiences with immunotherapy for metastatic kidney cancer

  This study is collecting information from people with advanced kidney cancer who have received certain immunotherapy combinations to see how well these treatments work in real life.

  Recruiting Hospital of Macerata · Province of Macerata, Macerata · NCT05287464

Related topics

Quick answers

How many Metastatic Renal Cell Carcinoma ( mRCC) clinical trials are recruiting right now?

6, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), China (2 trials), Russia (1 trial), Italy (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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