Drug or treatment

Fianlimab clinical trials

• 14Clinical trials
• 9Countries

Newest trials

All recruiting trials (14)

• Capecitabine/Oxaliplatin chemo with cemiplimab with or without fianlimab or REGN7075 for locally advanced rectal cancer

  This trial tests whether adding cemiplimab, cemiplimab with fianlimab, or cemiplimab with REGN7075 to CAPOX can help people with MSS locally advanced rectal cancer before surgery.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07281768

• Cemiplimab alone or with fianlimab after stereotactic body radiation for oligometastatic clear cell kidney cancer

  This trial will test whether giving cemiplimab alone or with fianlimab after stereotactic body radiation helps people with oligometastatic clear cell kidney cancer stay free of recurrence longer.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT07223541

• Comparing two immunotherapy combinations and their immune effects in unresectable or metastatic melanoma

  This will test whether two different first-line immunotherapy combinations produce different immune responses in tumors and blood of people with unresectable or metastatic melanoma.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07223411

• First-line immune-checkpoint antibody combinations for advanced clear cell kidney cancer

  This trial tests whether combining fianlimab and cemiplimab, with or without ipilimumab, works better than the standard ipilimumab plus nivolumab as first treatment for people with advanced clear cell kidney cancer.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · Washington D.C., District of Columbia and 4 other locations · NCT07188896

• Two immunotherapies after treatment for HPV-positive head and neck cancer

  This study tests whether adding fianlimab to cemiplimab helps prevent recurrence in adults with HPV-positive head and neck cancer who have detectable residual disease after initial therapy.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT07179315

• Cemiplimab alone or with Fianlimab or REGN7075 after surgery and chemo in colorectal cancer with minimal residual disease

  This study tests whether cemiplimab alone or in combination with fianlimab or REGN7075 can help prevent colorectal cancer from returning in adults who are ctDNA-positive after standard treatment.

  Recruiting at 13 sites Phase 2 NSABP Foundation Inc · Gainesville, Florida and 12 other locations · NCT07058012

• Using cemiplimab and fianlimab before surgery for non-small cell lung cancer

  This study is testing a combination of two drugs, cemiplimab and fianlimab, before surgery to see if they can help people with stage IB-IIIB non-small cell lung cancer respond better to treatment.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT06918132

• Treatment for BRAF Mutant Melanoma with Brain Metastases

  This study tests a new combination treatment for people with BRAF-mutated melanoma that has spread to the brain to see if it helps them live longer without their cancer getting worse.

  Recruiting at 17 sites Phase 2 Grupo Español Multidisciplinar de Melanoma · A Coruña, A Coruña and 17 other locations · NCT06887088

• Adding fianlimab to cemiplimab versus cemiplimab alone for recurrent or metastatic head and neck squamous cell carcinoma

  This test sees if adding the experimental drug fianlimab to cemiplimab works better than cemiplimab alone for people with recurrent or metastatic PD-L1–positive head and neck squamous cell carcinoma.

  Recruiting at 38 sites Phase 2 Regeneron Pharmaceuticals · Los Angeles, California and 37 other locations · NCT06769698

• Using cemiplimab and fianlimab before kidney cancer surgery

  This study is testing whether giving two immunotherapy drugs before kidney cancer surgery can safely shrink tumors in patients with high-risk non-metastatic clear cell renal cell carcinoma.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06699602

• Testing a new combination treatment for advanced melanoma

  This study is testing a new combination of three treatments for people with advanced melanoma that hasn't improved with other therapies to see if it can help them feel better.

  Recruiting at 12 sites Phase 2 Memorial Sloan Kettering Cancer Center · Los Angeles, California and 11 other locations · NCT06594991

• Combining two experimental drugs for advanced melanoma treatment

  This study is testing if a new combination of two experimental drugs can help people with advanced melanoma more than the current approved treatments.

  Recruiting at 92 sites Phase 3 Regeneron Pharmaceuticals · Chandler, Arizona and 112 other locations · NCT06246916

• Cemiplimab with or without Fianlimab for older patients with advanced colorectal cancer

  This study is testing whether a new combination of two immunotherapy drugs can help older patients with advanced colorectal cancer feel better and improve their treatment outcomes.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06205836

• Investigating the safety and effectiveness of REGN5668 with other drugs for advanced ovarian and uterine cancers

  This study is testing if a new drug called REGN5668, used with other medications, can safely help people with advanced ovarian or uterine cancers.

  Recruiting at 27 sites Phase 1/2 Regeneron Pharmaceuticals · Duarte, California and 27 other locations · NCT04590326

Quick answers

How many clinical trials of Fianlimab are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (13 trials), Spain (3 trials), France (2 trials), Canada (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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