Liquid biopsy to detect AXL-positive circulating tumor cells in pancreatic cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center protocol enrolls adults with treatment-naïve metastatic pancreatic adenocarcinoma and uses blood draws to isolate and enumerate circulating tumor cells (CTCs) that express the AXL receptor. Collected samples are analyzed with a sensitive CTC detection platform to identify AXL(+) cells and characterize their presence over time. The goal is to link presence and changes in AXL(+) CTCs with disease status, prognosis, and potential therapeutic markers. Procedures are non-invasive blood tests performed at CHU Montpellier and patients are followed according to the protocol schedule.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient is at least 18 years old;
* Patients with pancreatic cancer with remote metastases, naïve of any treatment, that is, eligible for a first line of treatment;
* Patients with oral consent

Exclusion Criteria:

* Non-affiliation or non-beneficiary of a Social Security regimen;
* Frailty persons according to Article L1121-6 of the CSP;
* Adult protected or unable to give consent as per Article L1121-8 of the CPMP;
* Pregnant or lactating women as per MSC L1121-5.
* Not included for monitoring difficulties (mutation, insufficient motivation, predictable poor compliance, priority associated pathology in care, etc.)

Where it's running

• CHU Montpellier
  Montpellier, France Recruiting

Study contacts

• Principal investigator: Catherine Alix-Panabières, PhD — University Hospital, Montpellier
• Study coordinator: Thomas Bardol, MD
• Email: t-bardol@chu-montpellier.fr
• Phone: +33682882757

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.