Evaluating FOLFIRINOX treatment for advanced pancreatic cancer

Phase II Trial Evaluating the Efficacy and the Safety of FOLFIRINOX3 Treatment in Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer in First Line of Chemotherapy (FOLFIRINOX3 Pancréas)

This study is testing if a specific chemotherapy called FOLFIRINOX can help people with advanced pancreatic cancer feel better and live longer compared to other treatments.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 90 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Centre Georges Francois Leclerc (other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Dijon)
• Trial ID: NCT05988814 on ClinicalTrials.gov

What this trial studies

This trial evaluates the efficacy and safety of FOLFIRINOX treatment as a first-line chemotherapy for patients with unresectable locally advanced or metastatic pancreatic cancer. Participants will receive a maximum of 16 courses of treatment, divided into two sets of 8 courses, followed by maintenance therapy until disease progression. The study aims to determine how effective this regimen is in improving patient outcomes compared to existing treatments.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 with unresectable locally advanced or metastatic pancreatic adenocarcinoma and a performance status of 0 or 1.

Not a fit: Patients with a history of chemotherapy for their condition within the last 12 months or those with uncontrolled comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve survival rates and quality of life for patients with advanced pancreatic cancer.

How similar studies have performed: Previous studies have shown promising results with FOLFIRINOX in similar patient populations, indicating a potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* Male or female age \> 18 years at time of study entry
* Performance status of 0 or 1 according to the Eastern Cooperative Oncology Group (ECOG)
* Patients with pancreatic adenocarcinoma
* Patients with unresectable locally advanced pancreatic cancer or metastatic pancreatic cancer
* Patients with no history of chemotherapy (prior adjuvant or neoadjuvant chemotherapy accepted if the time between the end of chemotherapy and recurrence is greater than 12 months) and no history of curative radiotherapy for metastatic or locally advanced disease. Palliative radiotherapy is accepted.
* Patient eligible for treatment with FOLFIRINOX (5-FU, Irinotecan, Oxaliplatin and folinic acid) including but not limited to: No active heart disease An ECG with a QT/QTc interval ˂ to 450 ms for men and ˂ to 470 ms for women. No uncontrolled hypertension defined by systolic pressure \> 140 mmHg or diastolic pressure \> 90 mmHg despite optimal medical management. A negative pregnancy test if applicable
* Tumor evaluation (CT scan) performed within 4 weeks (28 days) prior to inclusion with at least one measurable lesion according to RECIST 1.1 criteria
* Patient fit and able to comply with the protocol for the duration of the study, including treatment, visits, scheduled examinations and follow-up.
* Biological, hepatic, renal and serological data within the following limits (tests performed within 7 days of inclusion except for serologies performed within 28 days)
* Information given and informed consent signed
* Patient affiliated to a social security scheme
* Men and women must have an effective contraceptive method.

Exclusion Criteria:

* Patient with neuroendocrine carcinoma or acinar cell carcinoma
* Other cancer in the 5 years preceding inclusion or concomitant (except cancer in situ of the uterine cervix or cutaneous basal cell carcinoma).
* Presence of brain metastasis(es)
* Estimated prognosis \< 3 months
* History of grade 4 toxicity to oxaliplatin, irinotecan or 5FU if history of adjuvant/neoadjuvant chemotherapy
* Sequellar toxicity \> grade 1 if previous adjuvant/neoadjuvant chemotherapy
* Hypersensitivity to any component of FOLFIRINOX® treatment.
* Current participation or participation within 30 days prior to inclusion in another therapeutic trial with an investigational compound and/or completion of radiotherapy within 10 days prior to the start of treatment
* Evidence of a homozygous or heterozygous DPYD mutation and/or uracilemia \>16ng/mL and/or homozygous UGT1A1 genotype.
* Pregnancy, breastfeeding
* Inability to sign informed consent or to undergo medical monitoring of the trial for geographical, social or psychological reasons including, but not limited to, psychiatric illness compromising comprehension of information or conduct of the study.
* Patient under guardianship, curatorship or safeguard of justice.

Where this trial is running

Dijon

• Centre Georges-François Leclerc — Dijon, France (RECRUITING)

Study contacts

• Study coordinator: Jean-David FUMET, Dr

Conditions: Metastatic Pancreatic Cancer, FOLFIRINOX treatment, pancreatic cancer, first line chemotherapy