Combination treatment for advanced pancreatic cancer

mFOLFIRINOX Combined With Anlotinib and Sintilimab as First-Line Therapy for Locally Advanced or Metastatic Pancreatic Cancer: A Prospective, Single-arm, Multicenter, Phase Ib/II Clinical Study

This study is testing a new combination treatment for advanced pancreatic cancer to see if it helps patients who haven't had treatment before.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 29 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Fujian Provincial Hospital (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy, sintilimab, anlotinib
• Locations: 4 sites (Fuzhou, Fujian and 3 other locations)
• Trial ID: NCT06761027 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety and efficacy of a combination treatment using mFOLFIRINOX, anlotinib, and sintilimab in patients with locally advanced or metastatic pancreatic cancer who have not received prior treatment. It is a prospective, single-arm, multicenter trial that aims to assess treatment outcomes and explore potential biomarkers associated with the therapy. The study will enroll patients aged 18 to 75 with measurable lesions and an expected survival of at least three months.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with locally advanced or metastatic pancreatic cancer who have not undergone prior anti-cancer treatment.

Not a fit: Patients with severe organic diseases or those who have previously received anti-cancer treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced pancreatic cancer.

How similar studies have performed: While the combination of these specific treatments is novel, similar approaches in treating pancreatic cancer have shown promise in other studies.

Eligibility criteria

Inclusion Criteria:

1. Fully understand this study and voluntarily sign the informed consent form;
2. Age between 18 and 75 years inclusive, with no gender restrictions;
3. Patients with locally advanced or metastatic pancreatic cancer diagnosed by histology or cytology;
4. No prior anti-cancer treatment;
5. Patients must have at least one measurable lesion (according to RECIST 1.1 criteria);
6. ECOG PS score of 0-1;
7. Expected survival of at least 3 months;
8. No severe organic diseases of the heart, lungs, brain, liver, kidneys, or other organs;
9. Women of childbearing age must agree to use contraceptive measures during the treatment period and for 6 months after the end of treatment; negative serum or urine pregnancy test within 7 days before study enrollment, and must be non-lactating, men must agree to use contraceptive measures during the study period and for 6 months after the study ends.

Exclusion Criteria:

1. Have already received or are currently receiving additional anti-tumor treatment measures such as chemotherapy, radiotherapy, targeted therapy, immunotherapy, or traditional Chinese medicine treatment;
2. Known allergies to any of the drugs in the study;
3. Symptomatic brain metastases or metastases with symptom control time less than 2 months;
4. A large liver metastasis burden, occupying more than 70% of the liver volume;
5. Patients with obstructive jaundice whose bilirubin cannot be reduced to the expected level after adequate decompression;
6. Presence of any active autoimmune diseases or patients with autoimmune diseases expected to relapse (such as interstitial pneumonia, colitis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism, including but not limited to these diseases and syndromes);
7. History of immunodeficiency; patients currently using immunosuppressants, systemic corticosteroid therapy, or any other form of immunosuppressive treatment;
8. Known genetic or acquired bleeding tendencies (such as coagulation disorders) or thrombosis, such as hemophiliacs; currently using or have recently (within 10 days before the start of the study treatment) used full-dose oral or injectable anticoagulants or thrombolytic drugs for therapeutic purposes (preventive use of low-dose aspirin, low molecular weight heparin is allowed);
9. Serious infections (CTC AE greater than grade 2) occurred within 4 weeks before the first use of the study drug, such as severe pneumonia requiring hospitalization, bacteremia, infectious complications, etc.; baseline chest imaging suggests active pulmonary inflammation, presence of symptoms and signs of infection within 2 weeks before the first use of the study drug, or requiring oral or intravenous antibiotic treatment (excluding the use of antibiotics for prevention);
10. History of other malignant tumors within the past 5 years or concurrently, except for cured basal cell carcinoma of the skin, cervical carcinoma in situ, and papillary thyroid carcinoma;
11. Patients with mental illness; history of abuse of psychotropic drugs, alcoholism, and drug addiction;
12. Pregnant or lactating women;
13. Deemed by the investigator as unsuitable to participate in this trial for other reasons.

Where this trial is running

Fuzhou, Fujian and 3 other locations

• First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (Not_yet_recruiting)
• Fujian Provincial Hospital — Fuzhou, Fujian, China (Recruiting)
• Mengchao Hepatobiliary Hospital of Fujian Medical University — Fuzhou, Fujian, China (Not_yet_recruiting)
• Zhangzhou Affiliated Hospital of Fujian Medical University — Zhangzhou, Fujian, China (Not_yet_recruiting)

Study contacts

• Study coordinator: Mao-Lin Yan

Conditions Locally Advanced Pancreatic Cancer; Metastatic Pancreatic Cancer; anlotinib; sintilimab