Condition

Locally Advanced Non-Small Cell Lung Cancer clinical trials and research

• 13Clinical trials
• 13Countries

Newest Locally Advanced Non-Small Cell Lung Cancer clinical trials

All recruiting trials (13)

• Neoadjuvant PD-L1/VEGF Bispecific Antibody with Chemo versus Chemo plus PD-1 Monoclonal Antibody in Locally Advanced NSCLC

  In people with locally advanced NSCLC, this study tests whether adding a PD-L1/VEGF bispecific antibody to chemotherapy before surgery improves outcomes compared with a PD-1 antibody added to chemotherapy.

  Recruiting at 2 sites Phase 3 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, China and 4 other locations · NCT07863999

• Radiation-related heart damage in locally advanced NSCLC tested with PET-CT

  This study tests whether PET-CT imaging with 18F-Flurpiridaz can detect early radiation-related heart damage in adults with locally advanced non-small cell lung cancer receiving standard chemoradiation.

  Recruiting Phase 2 Indiana University · Indianapolis, Indiana · NCT07761910

• Targeted Induction Therapy for Stage III Unresectable EGFR Mutant NSCLC

  This trial tests a targeted induction approach using fumetinib with platinum-based chemotherapy and concurrent radiochemotherapy in adults with unresectable stage III EGFR-mutant NSCLC to see if this combo can improve outcomes before possible surgery.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT07742332

• DS-3939a in solid tumors and non-small cell lung cancer

  This study tests DS-3939a, alone or with other anticancer drugs, in adults with solid tumors including locally advanced or metastatic NSCLC to see if it is safe and helps control the disease.

  Recruiting at 3 sites Phase 1/2 Daiichi Sankyo · Fayetteville, Arkansas and 75 other locations · NCT07739966

• Induction chemoimmunotherapy plus chemoradiotherapy and consolidation immunotherapy in unresectable locally advanced NSCLC

  This trial tests induction chemoimmunotherapy followed by chemoradiotherapy and consolidation immunotherapy in adults with unresectable stage III NSCLC to see if it can improve outcomes compared with the standard PACIFIC approach.

  Recruiting Phase 1/2 Shanghai Chest Hospital · Shanghai, Xuhui · NCT07632365

• Neoadjuvant SBRT then sintilimab with chemotherapy for N3-positive locally advanced NSCLC

  This approach tests whether focused radiation to the primary lung tumor followed by two cycles of sintilimab plus platinum-based chemotherapy before surgery can shrink N3-positive locally advanced non-small cell lung cancer and enable curative surgery.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07309952

• NBTXR3 with radiation for locally advanced non-small cell lung cancer

  This study will test whether adding NBTXR3 to radiation helps people with stage I–III non-small cell lung cancer who cannot have chemotherapy or surgery.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT07224152

• Radiosensitivity-guided personalized adaptive radiotherapy for locally advanced non-small cell lung cancer

  This trial will test whether a radiosensitivity-guided personalized adaptive radiotherapy approach (RAPART) can improve survival for adults with unresectable locally advanced non-small cell lung cancer compared with standard 60 Gy radiotherapy.

  Recruiting Capital Medical University · Shenzhen, Guangdong · NCT07164885

• Hypofractionated versus conventional chemoradiotherapy followed by consolidative immunotherapy for locally advanced NSCLC

  This trial tests whether a shorter, higher-dose (hypofractionated) chemoradiotherapy course followed by up to 12 months of immunotherapy works as well or better than standard fractionated chemoradiotherapy plus the same immunotherapy for people with unresectable, locally advanced non-small cell lung cancer.

  Recruiting at 3 sites Phase 3 Sun Yat-sen University · Chongqing, Chongqing Municipality and 2 other locations · NCT07052669

• Combining Befotertinib with Bevacizumab or Chemotherapy for Lung Cancer Treatment

  This study is testing if a new lung cancer treatment combining befotertinib with either bevacizumab or chemotherapy can help patients with early-stage cancer that has an EGFR mutation feel better before surgery.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT06755684

• Combination of immunotherapy and chemotherapy for advanced lung cancer

  This study is testing if a new combination of immunotherapy and chemotherapy can help people with advanced lung cancer do better than the usual treatment.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06734702

• Testing lower doses of atezolizumab for cancer treatment

  This study is testing whether lower doses of atezolizumab can effectively treat adults with advanced cancer while causing fewer side effects.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06066138

• Management and follow-up for patients with advanced lung cancer

  This study is testing a new patient management system to see if it can help people with advanced lung cancer live longer and feel better during their treatment.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT05339568

Related topics

Quick answers

How many Locally Advanced Non-Small Cell Lung Cancer clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (10 trials), United States (4 trials), Argentina (1 trial), Austria (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 3, Phase 3: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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