Condition

Metastatic Colorectal Cancer (mCRC) clinical trials and research

• 10Clinical trials
• 10Countries

Newest Metastatic Colorectal Cancer (mCRC) clinical trials

All recruiting trials (10)

• Continuing cetuximab after first progression for metastatic colorectal cancer

  This study will test whether keeping cetuximab while switching the chemotherapy backbone helps adults with RAS/BRAF wild‑type metastatic colorectal cancer whose disease progressed after first‑line anti‑EGFR therapy.

  Recruiting Phase 3 University of Campania Luigi Vanvitelli · Ancona and 40 other locations · NCT07389265

• µCAN diagnostic to pick the best drugs for metastatic colorectal cancer

  This will test whether the µCAN lab test can identify the best drugs for people with metastatic colorectal cancer who are about to start a new line of treatment.

  Recruiting Oncosyne AS · Lørenskog, Akershus · NCT07171554

• Combining hydroxychloroquine with chemotherapy for advanced colorectal cancer

  This study is testing if adding hydroxychloroquine to standard chemotherapy can help people with advanced colorectal cancer live longer and feel better.

  Recruiting Phase 2 Pavlov First Saint Petersburg State Medical University · Saint Petersburg, Sankt-Peterburg · NCT06949982

• Effects of combined exercise on quality of life for colorectal cancer patients undergoing chemotherapy

  This study tests if an 18-week exercise program can improve the quality of life for colorectal cancer patients who are receiving chemotherapy.

  Recruiting at 4 sites Copenhagen University Hospital, Rigshospitalet · Copenhagen and 3 other locations · NCT06938971

• Testing a new treatment for metastatic colorectal cancer

  This study is testing a new treatment called arfolitixorin for people with metastatic colorectal cancer to see if it works better than the usual therapy.

  Recruiting Phase 1/2 Isofol Medical AB · Berlin and 2 other locations · NCT06922383

• Evaluating Fruquintinib for Metastatic Colorectal Cancer

  This study is testing how well Fruquintinib works for people with metastatic colorectal cancer who have already tried other treatments, to see how it affects their survival and quality of life.

  Recruiting at 42 sites iOMEDICO AG · Biberach, Baden-Wurttemberg and 41 other locations · NCT06787105

• Registry for patients with advanced metastatic colorectal cancer

  This study is collecting information from patients with advanced colorectal cancer who have tried different treatments to see how well they are doing and to help improve future care.

  Recruiting at 7 sites Arbeitsgemeinschaft medikamentoese Tumortherapie · Linz and 6 other locations · NCT06678919

• Screening for KRAS G12C mutations in metastatic colorectal cancer

  This study is testing a new kit to find out if people with metastatic colorectal cancer have a specific mutation so they can join a trial looking at a new treatment combination.

  Recruiting QIAGEN Gaithersburg, Inc · Manchester, Manchester · NCT06645236

• Evaluating HNF4α srRNA for treating metastatic colorectal cancer

  This study is testing a new treatment called HNF4α srRNA to see if it is safe and tolerable for people with advanced colorectal cancer that can't be surgically removed.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT06621173

• Combining PDS01ADC with targeted liver chemotherapy for certain cancers

  This study is testing if a new cancer treatment that combines an immune booster with targeted liver chemotherapy can help people with certain advanced cancers feel better and live longer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05286814

Related topics

Quick answers

How many Metastatic Colorectal Cancer (mCRC) clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in Germany (2 trials), Russia (1 trial), Norway (1 trial), United States (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Early Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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