Condition

Intrahepatic Cholangiocarcinoma (Icc) clinical trials and research

• 19Clinical trials
• 7Countries

Newest Intrahepatic Cholangiocarcinoma (Icc) clinical trials

All recruiting trials (19)

• Perioperative therapy with Retlirafusp alfa, Famitinib, and HAIC-GEMOX for locally advanced intrahepatic cholangiocarcinoma

  This trial tests whether a perioperative treatment combo (Retlirafusp alfa, famitinib, and HAIC-GEMOX) can help shrink or control locally advanced intrahepatic cholangiocarcinoma before surgery and support additional therapy afterward in adults.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07847710

• Protective effect of phycocyanin on liver injury after partial hepatectomy

  This study tests whether taking phycocyanin around liver surgery can reduce liver injury and help the liver recover in adults with intrahepatic cholangiocarcinoma.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07760038

• Adjuvant therapy after liver surgery for high-risk intrahepatic cholangiocarcinoma

  This real-world study tests three adjuvant treatment approaches after curative liver surgery in people with high-risk intrahepatic cholangiocarcinoma to see which option performs best.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07640048

• Scout-dose check using resin microspheres before yttrium-90 treatment for liver tumors

  This test tries a small 'scout' dose of the same resin microspheres used in yttrium-90 treatment to better measure lung shunt in adults with liver cancer or liver metastases.

  Recruiting Seoul National University Hospital · Seoul · NCT07476651

• 68Ga‑FAPI PET/CT imaging for biliary tract cancers

  We will test whether 68Ga‑FAPI PET/CT scans can find and stage gallbladder cancer and intrahepatic cholangiocarcinoma more accurately than standard FDG PET/CT in adults with suspected or known disease.

  Recruiting Tata Memorial Centre · Mumbai, Maharashtra · NCT07337850

• Blood test using cfDNA methylation to screen for biliary tract cancers

  This study tests whether a blood test that reads cfDNA methylation can detect biliary tract cancers early in adults with or suspected of having these cancers.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07176962

• Preoperative Lymph Node Assessment in Cholangiocarcinoma using Endoscopic Ultrasound

  This study tests how well preoperative endoscopic ultrasound (EUS) finds lymph node metastases in adults with presumed resectable or certain unresectable cholangiocarcinomas to see if surgery should proceed.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland and 5 other locations · NCT07161869

• Combining advanced ultrasound and molecular analyses to map tumor differences in liver cancer

  This project tries combining multiple ultrasound techniques with molecular (multi-omics) tests to see if they can better characterize tumors and guide care for adults with primary liver cancer who are scheduled for surgery.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07101237

• Cryoablation with lenvatinib and QL1706 for advanced intrahepatic cholangiocarcinoma

  We will try freezing tumors (cryoablation) together with the drugs lenvatinib and QL1706 in people whose advanced intrahepatic cholangiocarcinoma has worsened after first-line treatment.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07070700

• Postoperative concurrent chemoradiotherapy with simultaneous integrated boost for intrahepatic cholangiocarcinoma

  This treatment tests whether adding postoperative concurrent chemoradiotherapy with a simultaneous integrated boost plus oral capecitabine can reduce recurrence in adults after liver surgery for intrahepatic cholangiocarcinoma with narrow margins or positive lymph nodes.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT07063888

• Combining Apatinib, Adebrelimab, and Chemotherapy for Advanced Intrahepatic Cholangiocarcinoma

  This study is testing a new treatment that combines two medications with chemotherapy to see if it can help people with advanced liver cancer respond better than with standard chemotherapy alone.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06925516

• Direct chemotherapy delivery to the liver for bile duct cancer patients

  This study is testing if delivering chemotherapy directly to the liver can help adults with bile duct cancer live longer and feel better after surgery.

  Recruiting Phase 2 Erasmus Medical Center · Rotterdam, South Holland · NCT06888063

• Liver transplantation for patients with advanced bile duct cancer after treatment

  This study is testing if liver transplantation can help patients with advanced bile duct cancer who have managed to control their tumors with treatment.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan, Milan · NCT06862934

• Combining HAIC with Durvalumab and Lenvatinib for Advanced Intrahepatic Cholangiocarcinoma

  This study is testing a new treatment combining chemotherapy with two other drugs to see if it can help people with advanced bile duct cancer feel better and live longer.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT06859684

• Combination treatment for advanced intrahepatic cholangiocarcinoma and gallbladder cancer

  This study is testing a new combination treatment for people with advanced bile duct and gallbladder cancer to see if it can help them respond better to therapy and possibly become eligible for surgery.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tia · NCT06852287

• PET/CT with zirconium‑labelled girentuximab to image CAIX in liver and gastro‑entero‑pancreatic neuroendocrine tumors

  This will test whether a PET/CT scan using zirconium‑labelled girentuximab can find CAIX‑expressing hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and gastro‑entero‑pancreatic neuroendocrine tumors in adults.

  Recruiting Nantes University Hospital · Nantes and 1 other locations · NCT06735560

• Combining toripalimab with GemCis for treating resectable intrahepatic cholangiocarcinoma

  This study is testing if combining a new drug called toripalimab with standard chemotherapy can help people with resectable intrahepatic cholangiocarcinoma do better before surgery.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06721286

• Evaluating ICP-192 for patients with advanced intrahepatic cholangiocarcinoma

  This study is testing a new drug called ICP-192 to see if it can help people with advanced liver cancer that hasn't improved with other treatments.

  Recruiting at 5 sites Phase 2 Beijing InnoCare Pharma Tech Co., Ltd. · Hefei, Anhui and 43 other locations · NCT05678270

• Combining PDS01ADC with targeted liver chemotherapy for certain cancers

  This study is testing if a new cancer treatment that combines an immune booster with targeted liver chemotherapy can help people with certain advanced cancers feel better and live longer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05286814

Related topics

Quick answers

How many Intrahepatic Cholangiocarcinoma (Icc) clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (12 trials), Netherlands (2 trials), United States (1 trial), Italy (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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