Condition

Melanoma Metastatic clinical trials and research

• 9Clinical trials
• 8Countries

Newest Melanoma Metastatic clinical trials

All recruiting trials (9)

• Combo of tunlametinib, pucotenlimab, and hydroxychloroquine in NRAS-mutant melanoma

  This study tests whether adding hydroxychloroquine to tunlametinib and pucotenlimab helps people with NRAS-mutant melanoma.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07750067

• Fiber to boost gut bacteria and immunotherapy response in advanced melanoma

  In people with advanced melanoma starting immunotherapy, this trial tests whether increasing dietary fiber can grow beneficial gut bacteria and improve treatment response.

  Recruiting Phase 2 Radboud University Medical Center · Nijmegen, Gelderland and 1 other locations · NCT07686835

• Anti‑PD‑1 with a postbiotic for advanced, treatment‑naïve cutaneous melanoma

  This trial will test whether adding a postbiotic to anti‑PD‑1 immunotherapy helps boost tumor immune markers and improve outcomes in people with untreated stage IIIC or IV cutaneous melanoma.

  Recruiting Azienda Ospedaliera di Perugia · Bari, BA and 4 other locations · NCT07050940

• Using modified T cells to treat advanced melanoma and sarcoma

  This study is testing a new treatment that uses modified T-cells to see if it can help people with advanced melanoma and sarcoma fight their cancer better.

  Recruiting Phase 1 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud and 1 other locations · NCT06889766

• Combining multimodal tumor ablation with immunotherapy for liver metastases

  This trial will test whether adding the immunotherapy drug pucotenlimab to multimodal thermal ablation helps people with liver metastases from colorectal cancer, triple-negative breast cancer, or melanoma.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06889610

• Evaluating Oral Impact® with Anti PD-1 Treatment for Advanced Melanoma

  This study is testing if Oral Impact® can help people with advanced melanoma have fewer side effects when they start treatment with an immune therapy called nivolumab.

  Recruiting Fondazione Melanoma Onlus · Naples · NCT06880198

• Assessing a test to predict treatment response in advanced melanoma patients

  This study tests if the IOpener® melanoma test can help predict how well treatment will work for people with advanced melanoma who are starting their first-line therapy.

  Recruiting at 3 sites Pamgene International B.V. · Tübingen, Baden-Wurttemberg and 2 other locations · NCT06784778

• T-cell therapy using CRISPR-edited immune cells for metastatic melanoma

  This study is testing if a new treatment using modified immune cells can help people with advanced melanoma fight their cancer better.

  Recruiting Phase 1 Herlev Hospital · Herlev, Capital Region · NCT06783270

• Combining targeted radiotherapy with immunotherapy for advanced melanoma

  This study is testing if combining targeted radiotherapy with immunotherapy can help people with advanced melanoma live better and longer compared to just using immunotherapy alone.

  Recruiting at 5 sites Phase 2 Melanoma Institute Australia · Westmead, New South Wales and 4 other locations · NCT06767306

Related topics

Quick answers

How many Melanoma Metastatic clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in Italy (2 trials), China (2 trials), Australia (1 trial), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →