Optimizing tafenoquine dose to prevent relapse of vivax malaria in Asia
Official title: Optimizing the dose of tafenoquine for the radical cure of Plasmodium vivax malaria in Southeast Asia
Funded at University of Oxford · NIH-11619580 · Data updated 2026-11-12
A study tests the best tafenoquine dose to prevent P. vivax malaria relapse in people in East Asia and Oceania.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oxford NIH-funded |
| Lab location | 1 site (Oxford, United Kingdom) |
| Project start | September 8, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $117,395 |
| NIH project number | 3U01AI165321-04S1 |
| Project ID | NIH-11619580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients in East Asia and Oceania with Plasmodium vivax malaria, including adults and children, potentially over a range of G6PD activity.
✕Less likely to help
Patients with very low G6PD activity or contraindications to tafenoquine may not benefit.
What this research studies
This project analyzes how different tafenoquine doses perform in preventing relapse of vivax malaria in adults and children in Asia. Researchers use previously collected trial data to understand how dose affects recurrence risk. The goal is to identify a dosing strategy that maximizes cure rates while remaining safe for people with varying G6PD activity. Results could lead to more effective, single-dose treatment options for patients and reduce malaria-related illness.
Why it matters
Potential benefit: If successful, patients could receive a more effective and simpler single-dose treatment to prevent malaria relapse.
How similar studies have gone: Previous trials showed dose-dependent efficacy; this analysis builds on those findings with individual patient data.
Where this research is happening
-
University of Oxford
Oxford, United Kingdom Active
Researchers
- Principal investigator: Chu, Cindy S — University of Oxford
- Study coordinator: Chu, Cindy S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.