Condition

Langerhans Cell Histiocytosis (LCH) clinical trials and research

• 5Clinical trials
• 3Countries

Newest Langerhans Cell Histiocytosis (LCH) clinical trials

All recruiting trials (5)

• Dabrafenib and trametinib for rare cancers with BRAF V600 mutations

  This arm tests whether dabrafenib and trametinib can help adults, children, and teens with cancers that have a BRAF V600 mutation.

  Recruiting at 15 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT07440290

• Modified LCH-III chemotherapy with or without luvometinib for multisystem pediatric LCH

  This trial will test whether adding luvometinib to a modified LCH-III chemotherapy plan helps children (ages 0–18) with multisystem Langerhans cell histiocytosis stay in remission longer.

  Recruiting at 11 sites West China Second University Hospital · Chengdu and 10 other locations · NCT07431060

• Luvometinib for children with single-system multifocal or special-site bone LCH

  This project tests whether the drug luvometinib can help children with Langerhans cell histiocytosis that affects certain bones or has multiple bone lesions.

  Recruiting at 11 sites West China Second University Hospital · Hefei, Anhui and 10 other locations · NCT07371182

• Dabrafenib or Trametinib plus Clofarabine for high-risk or relapsed pediatric Langerhans cell histiocytosis

  This treatment will test whether adding a MAPK inhibitor (dabrafenib or trametinib) to the chemotherapy drug clofarabine helps children and teens (0–18) with high-risk, recurrent, or refractory Langerhans cell histiocytosis.

  Recruiting Phase 2 West China Second University Hospital · Chengdu, Sichuan · NCT07022834

• Treatment with mirdametinib for histiocytic disorders

  This study is testing a new treatment called mirdametinib to see if it helps people with Langerhans cell histiocytosis and other histiocytic disorders feel better with fewer side effects than current options.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06153173

Related topics

Quick answers

How many Langerhans Cell Histiocytosis (LCH) clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in China (3 trials), United Kingdom (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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