Condition

High-Risk Neuroblastoma clinical trials and research

• 11Clinical trials
• 4NIH research projects
• 25Countries

Newest High-Risk Neuroblastoma clinical trials

All recruiting trials (11)

• Dinutuximab-beta with chemotherapy in newly diagnosed high-risk neuroblastoma

  This pilot study tests whether adding the antibody dinutuximab-beta to standard induction chemotherapy is safe and helps shrink tumors in kids and young adults with newly diagnosed high-risk neuroblastoma.

  Recruiting at 2 sites Phase 1 Chang Gung Memorial Hospital · Taipei, Taiwan and 1 other locations · NCT07688252

• hu14.18K322A with temozolomide and irinotecan for relapsed or refractory high‑risk neuroblastoma

  This trial will test whether the anti‑GD2 antibody hu14.18K322A given with temozolomide and irinotecan helps children and teens (18 months to 18 years) with relapsed or refractory high‑risk neuroblastoma.

  Recruiting at 20 sites Phase 2/3 Renaissance Pharma Ltd. · San Francisco, California and 19 other locations · NCT07549321

• Naxitamab added to standard induction therapy for newly diagnosed high-risk neuroblastoma

  This study tests whether adding Naxitamab and GM-CSF to the standard induction therapy improves outcomes for children and young people with newly diagnosed high-risk neuroblastoma.

  Recruiting Phase 2 Shaare Zedek Medical Center · Jerusalem · NCT07537400

• Dual-target GD2 and B7-H3 CAR-NK therapy for children and young adults with relapsed or refractory neuroblastoma

  This trial tries an off-the-shelf CAR-NK cell treatment that targets GD2 and B7-H3 for children and young adults whose high-risk neuroblastoma has returned or not responded to prior therapy.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07502287

• Supportive care intervention for low-income children with high-risk neuroblastoma

  This study is testing a new supportive care program for low-income children with high-risk neuroblastoma to see if it helps them and their families feel better during treatment.

  Recruiting at 6 sites Dana-Farber Cancer Institute · Hartford, Connecticut and 5 other locations · NCT06831552

• Treatment with CAR T cells for high-risk neuroblastoma in children

  This study is testing a new CAR T cell treatment for children with hard-to-treat neuroblastoma to see if it is safe and how well it works.

  Recruiting at 2 sites Phase 1/2 Boston Children's Hospital · Boston, Massachusetts and 1 other locations · NCT06803875

• Combining Lutathera® and Olaparib for treating recurrent solid tumors in children and adolescents

  This study is testing if combining Lutathera® with olaparib can help children and teenagers with hard-to-treat solid tumors that have certain receptors.

  Recruiting Phase 1/2 Fundación de investigación HM · Boadilla del Monte, Madrid · NCT06607692

• Reduced chemotherapy and antibody treatment for children with high-risk neuroblastoma

  This study is testing a new, lighter chemotherapy and antibody treatment for children with high-risk neuroblastoma to see if it helps them get better.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06528496

• Testing a vaccine with beta-glucan for high-risk neuroblastoma patients

  This study is testing a new vaccine combined with a substance called beta-glucan to see if it can help children with high-risk neuroblastoma who are in complete remission.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06057948

• Using dinutuximab beta with chemotherapy to treat high-risk neuroblastoma in children

  This study is testing if a new treatment combining dinutuximab beta with chemotherapy can help children with high-risk neuroblastoma who haven't responded to other treatments.

  Recruiting Phase 1 Jagiellonian University · Krakow, Malopolska · NCT05272371

• Treatment for high-risk neuroblastoma

  This study is testing different chemotherapy and radiation treatments to see which ones work best for children with high-risk neuroblastoma.

  Recruiting at 106 sites Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Sydney, Randwick and 141 other locations · NCT04221035

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ADEPT-STAR therapy for high risk neuroblastoma

  A new cell-based therapy approach aims to help children with high-risk neuroblastoma by using off-the-shelf, donor-derived treatments.

  NIH research Expression Therapeutics · Tucker, United States · NIH-11407954

• Reading RNA in individual cells from high-risk childhood neuroblastoma

  This project uses long-read RNA sequencing on single tumor cells to find cancer-specific surface proteins that might become new immune therapy targets for children with high-risk neuroblastoma.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11248384

• Investigating new targets for treating high-risk neuroblastoma in children

  This study is looking at a tough childhood cancer called high-risk neuroblastoma to find new ways to help treat it, by examining tumor samples to discover unique proteins that could be targeted by new immunotherapies, like CAR T cells, to improve treatment for kids facing this illness.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11063464

• Targeting calcium signaling to treat relapsed high-risk neuroblastoma

  This study is exploring new ways to treat relapsed high-risk neuroblastoma in kids by using a special drug that targets how cancer cells handle calcium, hoping to help those whose cancer hasn't responded to other treatments.

  NIH research Western New England University · Springfield, United States · NIH-10795286

Related topics

Quick answers

How many High-Risk Neuroblastoma clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (5 trials), Spain (3 trials), Denmark (2 trials), France (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 3, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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