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Hepato Cellular Carcinoma (HCC) clinical trials and research

• 16Clinical trials
• 1New in 30 days
• 8Countries

Newest Hepato Cellular Carcinoma (HCC) clinical trials

All recruiting trials (16)

• Anatomic vs nonanatomic liver resection after conversion therapy for liver cancer

  This study tests whether removing more precisely targeted liver tissue (anatomic resection) works better than removing tissue more broadly (nonanatomic) for patients whose unresectable liver cancer became eligible for surgery after PD-1/PD-L1–based therapy.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT07927452

• Impact of Anesthesia on Inflammation and NETosis During HCC Ablation

  This study tests whether a propofol–fentanyl anesthesia plan with lidocaine during radiofrequency ablation for hepatocellular carcinoma affects inflammation and NETosis in patients with small tumors.

  Recruiting Iuliu Hatieganu University of Medicine and Pharmacy · Cluj-Napoca, Cluj · NCT07657897

• Pre-emptive topical indomethacin to prevent sorafenib-related hand-foot syndrome in advanced liver cancer

  This trial will test whether applying 1% indomethacin gel to both hands twice daily can reduce hand-foot syndrome in adults with advanced hepatocellular carcinoma starting sorafenib.

  Recruiting Phase 2 National Taiwan University Hospital · Taipei · NCT07560566

• Becotatug vedotin (MRG003) for previously treated advanced liver cancer with EGFR testing

  This study will test whether Becotatug vedotin (MRG003) helps people with advanced hepatocellular carcinoma whose cancer progressed after PD‑1/L1 therapy.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07536789

• TACE or Ablation With Sintilimab and Ipilimumab Before Surgery for Liver Cancer

  This study tests whether combining local tumor treatments with immunotherapy before surgery helps people with resectable hepatocellular carcinoma at higher risk of recurrence.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07487662

• Personalized adaptive second-line treatments for advanced liver cancer

  This trial tries different personalized second-line treatments to find which work best for people with advanced hepatocellular carcinoma after first-line immunotherapy-based regimens stop working.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT07328009

• TACE with doxorubicin plus ABCB1 blocker nicardipine versus standard TACE for liver cancer

  This trial tests whether adding the ABCB1 blocker nicardipine to doxorubicin-based TACE helps people with hepatocellular carcinoma (tumors 3–8 cm) get better tumor control than standard TACE alone.

  Recruiting at 3 sites Phase 2/3 University Hospital, Basel, Switzerland · Basel and 2 other locations · NCT07302919

• Using fecal microbiota transplantation to try to restore response to atezolizumab and bevacizumab in people with unresectable hepatocellular carcinoma.

  This will try whether giving a fecal microbiota transplant and then restarting atezolizumab plus bevacizumab can restore treatment response in adults with unresectable HCC who progressed early on those drugs.

  Recruiting Phase 2 IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO · NCT07276100

• Camrelizumab plus apatinib with or without FOLFOX chemotherapy for advanced liver cancer

  This research will test whether adding FOLFOX chemotherapy to camrelizumab plus apatinib helps adults with advanced hepatocellular carcinoma who have not received prior systemic treatment.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07267806

• Detecting hepatocellular carcinoma with the Delta-HLD blood test

  This project will test whether the Delta-HLD liquid biopsy can detect hepatocellular carcinoma (HCC) using blood and matched liver tissue from people with HCC and from people with cirrhosis without cancer.

  Recruiting Epiliquid Holding, Inc · Mendoza · NCT07148310

• How ALPPS surgery affects liver regrowth after major liver cancer operations

  This project will follow adults with liver cancer who undergo ALPPS surgery to see if the quickly regrown liver tissue works well and how that relates to cancer coming back.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07142213

• Outpatient versus inpatient care for catheter-based treatment of primary liver cancer (CHOC)

  This trial will see if having TACE or TARE as an outpatient (ambulatory) procedure is as safe and more satisfying than staying in the hospital for adults with hepatocellular carcinoma or intrahepatic cholangiocarcinoma.

  Recruiting at 16 sites University Hospital, Angers · Amiens and 18 other locations · NCT06990659

• Evaluating PIVKA-II levels in liver cancer patients with portal vein thrombosis

  This study is trying to see if measuring a specific protein in the blood can help tell if liver cancer patients have a blockage in their portal vein caused by the tumor.

  Recruiting Tanta University · Tanta, Gharbyea · NCT06960954

• Evaluating liver stiffness to predict immunotherapy response in liver cancer

  This study is testing if a special scan can help predict how well people with advanced liver cancer will respond to immunotherapy treatment.

  Recruiting Tanta University · Tanta, Gharbyea · NCT06960863

• Combining HAIC with Donafenib and Sintilimab for Liver Cancer Treatment

  This study is testing if a new combination of chemotherapy and medications can help people with liver cancer who are at high risk of their cancer coming back after surgery.

  Recruiting Phase 2 Fudan University · Fuzhou, Fujian and 2 other locations · NCT06812039

• Combining PD-L1 antibody and Bevacizumab with chemotherapy for advanced liver cancer

  This study is testing a new combination of treatments for people with advanced liver cancer to see if it can help them live longer and feel better.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT06742424

Related topics

Quick answers

How many Hepato Cellular Carcinoma (HCC) clinical trials are recruiting right now?

16, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (8 trials), Egypt (2 trials), Italy (1 trial), Switzerland (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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