Evaluating PIVKA-II levels in liver cancer patients with portal vein thrombosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the relationship between Prothrombin induced by vitamin K absence II (PIVKA-II) serum levels and the presence of portal vein tumor thrombosis (PVTT) in patients diagnosed with hepatocellular carcinoma (HCC). Researchers will compare PIVKA-II levels in HCC patients who have PVTT against those who do not. Participants will undergo a series of evaluations including clinical examinations, laboratory tests, and imaging studies to determine tumor characteristics and the presence of PVTT. The study seeks to enhance understanding of PIVKA-II as a potential biomarker for PVTT in HCC patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patients older than 18 years.
* Patients with confirmed HCC with or without PVTT (Diagnosed by two imaging modalities or one imaging modality with elevated serum alpha fetoprotein or liver biopsy).

Exclusion Criteria:

* Prior locoregional therapy or liver transplantation.
* Patients on vitamin K, vitamin K antagonists or antibiotics.
* Patients with cholestasis.
* Patients with renal insufficiency.
* Patients with other malignancies.
* Unwilling to participate in our study.

Where it's running

• Tanta University Hospitals
  Tanta, Gharbyea, Egypt Recruiting

Study contacts

• Study coordinator: Rania M Elkafoury, MD
• Email: rania.elkafoury@med.tanta.edu.eg
• Phone: +201004672358

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.