Impact of Anesthesia on Inflammation and NETosis During HCC Ablation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines the perioperative inflammatory response and NETosis during radiofrequency ablation for hepatocellular carcinoma. Participants have solitary tumors up to 3 cm and are scheduled for RFA, receiving a sedation regimen of propofol, fentanyl, and lidocaine. The goal is to determine if anesthesia choices influence periprocedural prognosis, recurrence, and survival by measuring NETosis-related biomarkers. The trial is conducted at a single Romanian center under institutional leadership with no stated collaborator sites. Eligibility includes adults with ASA I–III status who are suitable for RFA and excludes those undergoing surgery or with conditions that could confound biomarker interpretation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with a hepatocellular carcinoma suitable for RFA
* tumor measuring up to 3 cm in diameter
* ASA I, II, or III

Exclusion Criteria:

* candidates for surgery
* chronic immunosuppressive medication
* contraindications to any of the study medications
* patients with psychiatric disorders
* autoimmune disorders
* corticosteroid-dependent bronchial asthma
* congenital or acquired coagulation disorders
* HIV-positive patients
* pregnant women
* antiarrhythmic therapy

Where it's running

• "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
  Cluj-Napoca, Cluj, Romania Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.