Understanding the signals that drive head and neck cancer
Official title: System-Level Analyses of Multi-Omics Data to Reveal Mechanisms of Head & Neck Cancer
Funded at Boston University Medical Campus · NIH-10763417 · Data updated 2026-11-12
This study is looking into how head and neck cancer develops and grows, hoping to find new ways to treat it better by understanding the genetic changes and signals in the cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 17, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $426,194 |
| NIH project number | 5R01DE031831-03 |
| Project ID | NIH-10763417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma, particularly those with advanced disease.
✕Less likely to help
Patients with early-stage head and neck cancer or those with other types of cancers may not benefit from this specific research.
What this research studies
This research investigates the mechanisms behind head and neck squamous cell carcinoma (HNSCC), a type of cancer with a low survival rate. By analyzing multi-omics data, the study aims to uncover the biological signals that contribute to the initiation and progression of this disease. The approach includes examining genetic alterations and their impact on cell signaling pathways, particularly focusing on the role of β-catenin and its interactions with other proteins. The goal is to identify potential therapeutic targets that could lead to improved treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with head and neck cancer.
How similar studies have gone: Previous research has shown promise in understanding cancer mechanisms through multi-omics approaches, indicating potential for success in this area.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Monti, Stefano — Boston University Medical Campus
- Study coordinator: Monti, Stefano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.