Understanding the signals that drive head and neck cancer
System-Level Analyses of Multi-Omics Data to Reveal Mechanisms of Head & Neck Cancer
This study is looking into how head and neck cancer develops and grows, hoping to find new ways to treat it better by understanding the genetic changes and signals in the cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10763417 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind head and neck squamous cell carcinoma (HNSCC), a type of cancer with a low survival rate. By analyzing multi-omics data, the study aims to uncover the biological signals that contribute to the initiation and progression of this disease. The approach includes examining genetic alterations and their impact on cell signaling pathways, particularly focusing on the role of β-catenin and its interactions with other proteins. The goal is to identify potential therapeutic targets that could lead to improved treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma, particularly those with advanced disease.
Not a fit: Patients with early-stage head and neck cancer or those with other types of cancers may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with head and neck cancer.
How similar studies have performed: Previous research has shown promise in understanding cancer mechanisms through multi-omics approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Monti, Stefano — Boston University Medical Campus
- Study coordinator: Monti, Stefano
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.