Exploring HPV and Genomic Changes in Head and Neck Cancer
Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh
This study is trying to see how common HPV is in head and neck cancer patients in Bangladesh and what changes it causes in their cells.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 550 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Academic / other |
| Locations | 1 site (Dhaka, Dhaka Division) |
| Trial ID | NCT06642324 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the prevalence and risk factors of head and neck squamous cell carcinoma (HNSCC) in Bangladesh, particularly focusing on the role of human papillomavirus (HPV) in its development. The study aims to identify the biological mechanisms and genomic changes associated with HPV-driven HNSCC by analyzing histopathology samples and conducting molecular screenings. By understanding these factors, the research seeks to provide insights into the public health challenges posed by HNSCC in the region.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been diagnosed with head and neck squamous cell carcinoma.
Not a fit: Patients with cancers outside the head and neck region or those under 18 years old will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and prevention strategies for HPV-associated head and neck cancers in Bangladesh.
How similar studies have performed: Other studies have shown success in exploring HPV's role in head and neck cancers, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient Age: adult (\> 18 years) 2. Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC). 3. Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue) 4. Patient's Consent Exclusion Criteria: 1. Patient Age: children (\< 18 years) 2. Cancers of any part of the body other than the head-neck region. 3. People without HNSCC 4. Any chronic diseases, genetic diseases, acute/chronic infectious diseases, etc. -
Where this trial is running
Dhaka, Dhaka Division
- Bangabandhu Sheikh Mujib Medical University (BSMMU) — Dhaka, Dhaka Division, Bangladesh (Recruiting)
Study contacts
- Principal investigator: S M Rashed Ul Islam, M. Phil, MPH — Bangabandhu Sheikh Mujib Medical University (BSMMU)
- Study coordinator: S M Rashed Ul Islam, M. Phil, MPH
- Email: smrashed@bsmmu.edu.bd
- Phone: +8801713236399
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.