Exploring new treatment targets for head and neck cancers
A Cohort Study to Identify Newer Therapeutic Targets in Head and Neck Cancers
Banaras Hindu University · NCT05382585
This study is trying to find out how certain genetic changes and HPV relate to head and neck cancers in patients with oral squamous cell carcinoma to help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Banaras Hindu University (other) |
| Locations | 1 site (Varanasi, Uttar Pradesh) |
| Trial ID | NCT05382585 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with squamous cell carcinoma of the oral cavity to investigate the role of specific genetic mutations in tumorigenesis. It involves comprehensive patient evaluations, including physical examinations, biopsies, and imaging studies to assess tumor characteristics. The study utilizes next-generation sequencing to analyze genetic alterations in tumor samples, aiming to identify predictive biomarkers that could guide treatment decisions. Additionally, HPV typing will be performed to understand its association with head and neck cancers.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with histologically confirmed primary head and neck cancers.
Not a fit: Patients under 18 years of age, pregnant or lactating women, and those with multiple cancers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostication and personalized treatment strategies for patients with head and neck cancers.
How similar studies have performed: Other studies utilizing next-generation sequencing for cancer biomarker identification have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histologically proven cases of primary head and neck cancers. Exclusion Criteria: * Patients under 18 years of age * Pregnant and lactating women * Multiple cancers or patients with cancer of other sites.
Where this trial is running
Varanasi, Uttar Pradesh
- Banaras Hindu University — Varanasi, Uttar Pradesh, India (RECRUITING)
Study contacts
- Principal investigator: Manoj Pandey, MS, PhD — Professor
- Study coordinator: Manoj Pandey, MS, PhD
- Email: manojpandey66@gmail.com
- Phone: 9336363640
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Head Neck Cancer, Oral Cancer, Next generation sequencing, predictive biomarker