Exploring new treatment targets for head and neck cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with squamous cell carcinoma of the oral cavity to investigate the role of specific genetic mutations in tumorigenesis. It involves comprehensive patient evaluations, including physical examinations, biopsies, and imaging studies to assess tumor characteristics. The study utilizes next-generation sequencing to analyze genetic alterations in tumor samples, aiming to identify predictive biomarkers that could guide treatment decisions. Additionally, HPV typing will be performed to understand its association with head and neck cancers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically proven cases of primary head and neck cancers.

Exclusion Criteria:

* Patients under 18 years of age
* Pregnant and lactating women
* Multiple cancers or patients with cancer of other sites.

Where it's running

• Banaras Hindu University
  Varanasi, Uttar Pradesh, India Recruiting

Study contacts

• Principal investigator: Manoj Pandey, MS, PhD — Professor
• Study coordinator: Manoj Pandey, MS, PhD
• Email: manojpandey66@gmail.com
• Phone: 9336363640

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Intratumoral fluorescent nivolumab before surgery in head and neck cancer

  This study tests injecting fluorescently labeled nivolumab directly into head and neck tumors to see if it is safe and whether it reaches nearby lymph nodes before surgical removal.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07741565

• BupiZenge vs Lidocaine for mouth pain from oral mucositis in head and neck cancer

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• Proton Re-irradiation for Head and Neck Cancer Recurrence

  This study tests whether proton therapy as a second round of radiation is safe and helpful for adults with head and neck cancer that has come back after prior treatment.

  Recruiting Istituto Clinico Humanitas · Rozzano, Milano · NCT07635641

• Intratumoral EDS01 plus toripalimab for recurrent or metastatic head and neck cancer

  This phase 1 study tests whether directly injecting a gene‑therapy endostatin product (EDS01) into a tumor, together with the PD-1 inhibitor toripalimab, is safe and shows early signs of activity in adults with recurrent or metastatic head and neck cancer after platinum therapy.

  Recruiting Phase 1 West China Hospital · Chengdu, China · NCT07625423

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.