Condition

Gastrointestinal Cancers clinical trials and research

• 11Clinical trials
• 13NIH research projects
• 12Countries

Newest Gastrointestinal Cancers clinical trials

All recruiting trials (11)

• PD-L1-targeted PET probe to map PD-L1 in solid tumors

  A PET tracer called 18F-F-PDL1-3 is being tested to see if it can detect PD-L1 expression in primary and metastatic tumors to help guide personalized treatment.

  Recruiting Phase 2 Peking University Cancer Hospital & Institute · Beijing · NCT07848243

• Pan-digestive tract cancer screening using blood methylation and fecal biomarkers

  This study tests a combined blood and stool biomarker approach to screen for cancers throughout the digestive tract in adults awaiting endoscopy.

  Recruiting at 7 sites Xijing Hospital · Zhaoqing, Guangdong and 6 other locations · NCT07769892

• Rina-S for advanced gastrointestinal cancers

  This Phase 2 trial will try Rina-S alone in people with metastatic or unresectable gastrointestinal cancers that have progressed after standard treatments to see if it can control the disease.

  Recruiting at 28 sites Phase 2 Genmab · Los Angeles, California and 27 other locations · NCT07539311

• BHB810 in advanced gastric and GEJ cancer (early-phase)

  This study tests whether BHB810 can be safely given every two weeks to adults with advanced gastric or GEJ adenocarcinoma and looks at its effect, how the drug behaves in the body, and patient responses.

  Recruiting at 2 sites Phase 1/2 BigHat Biosciences, Inc. · Duarte, California and 2 other locations · NCT07529808

• Using CYTALUX (pafolacianine) with a near-infrared camera to help find cancer during surgery

  This trial will test whether a single injection of CYTALUX (pafolacianine) helps surgeons see gastrointestinal, foregut, pancreatic, hepatobiliary, esophageal, and gynecologic cancers during surgery using a special near-infrared camera.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07039526

• Using Entecavir to Prevent Hepatitis B Reactivation in Gastrointestinal Cancer Patients

  This study is testing whether giving the antiviral drug entecavir early or only when needed can help prevent hepatitis B from getting worse in patients with gastrointestinal cancer who carry the virus.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06966232

• Social needs screening and connection program for Metro Detroit cancer survivors

  This project will test whether cancer survivors in Metro Detroit can complete a social needs screening and be connected to community resources for food and digital access.

  Recruiting Barbara Ann Karmanos Cancer Institute · Detroit, Michigan · NCT06908629

• Evaluating pain management methods for minimally invasive cancer surgery

  This study is testing which pain management method works best for people undergoing minimally invasive cancer surgery by comparing three different approaches.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT06731998

• Evaluating new imaging technology for cancer radiation therapy

  This study is testing a new imaging technology for cancer radiation therapy to see if it can provide better pictures than the standard method, helping patients get more effective treatment.

  Recruiting at 4 sites Varian, a Siemens Healthineers Company · Columbus, Ohio and 3 other locations · NCT06681233

• Using electroacupuncture and acupressure to prevent hand-foot syndrome in breast cancer patients on capecitabine

  This study is testing if combining electroacupuncture with self-acupressure can help prevent hand-foot syndrome in breast cancer patients taking capecitabine.

  Recruiting Affiliated Hospital of Qinghai University · Xining, Qinghai · NCT06602167

• Personalized self-management program to help colorectal cancer survivors adopt healthier habits

  This study will test whether a 6-week personalized self-management program helps colorectal and other gastrointestinal cancer survivors stick to healthy behavior recommendations better than a standardized program.

  Recruiting University of Southern California · Los Angeles, California and 1 other locations · NCT05984589

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Bacterial biosensors to detect and help prevent GI cancers

  A team is building living bacterial sensors that could detect colorectal and pancreatic tumors inside the gut and give a clear diagnostic signal.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11532955

• Gastrointestinal cancers: how stem cells and their environment shape cancer growth

  A research project at Columbia University Health Sciences studies how stomach, esophagus, and other GI cancers start and evolve by looking at stem cells, nerve signals, and the surrounding tissue.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11391403

• Bacterial biosensors to help detect GI cancers early

  A living bacterial sensor is being developed to spot colorectal and pancreatic cancers early inside the GI tract and give a readable diagnostic output.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11389304

• DPYD Genetic Testing in Community Cancer Care to Prevent Fluoropyrimidine Toxicity

  A community-based study will test whether offering DPYD genetic testing before chemotherapy with FP drugs reduces severe side effects and hospitalizations for people with GI cancers.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11340343

• Cell signaling and gene regulation in liver and gastrointestinal cancers

  Researchers are looking at how signaling proteins and gene-regulating enzymes like SIRT6 interact to explain why fatty liver disease can turn into liver cancer.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11308736

• Understanding and Improving Chemoradiation Response in Esophagogastric and Pancreatic Cancer

  This grant aims to learn why esophagogastric and pancreatic cancers resist standard chemoradiation and to use that knowledge to guide better, biomarker-driven treatments.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11263056

• How stem cells and nearby tissues drive cancers of the stomach, esophagus, colon, and pancreas

  Researchers are looking at how stem cells and surrounding tissues, including nerves, change during long-term inflammation and lead to gastrointestinal cancers so people with conditions like gastritis, Barrett's esophagus, colitis, or pancreatitis might benefit from better prevention or early detection.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11175365

• Understanding how certain proteins affect liver and gastrointestinal cancers

  This study is looking at how certain proteins in the liver interact with each other and how this might affect the development of liver cancer in people with a liver condition called NASH, with the hope of finding new ways to treat or prevent cancer.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11067815

• Support program for patients and caregivers with advanced gynecologic and gastrointestinal cancers

  This program pairs patients and their caregivers with a nurse, regular telehealth check-ins, and a symptom-tracking app to help manage severe symptoms and reduce hospital visits for people with advanced GI or gynecologic cancers.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11008925

• Using MAIT cells to treat gastrointestinal cancers

  This study is looking at a new way to help people with advanced colon cancer by using special immune cells called MAIT cells to fight tumors better, especially when other treatments aren't working as well.

  NIH research University of Utah · Salt Lake City, United States · NIH-10865685

• Improving support for patients and caregivers dealing with advanced cancers

  This study is testing a new program called BOLSTER to help people with advanced gastrointestinal and gynecologic cancers feel better and manage their symptoms at home, with support from healthcare professionals and easy check-ins through a mobile app.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10770546

• Training future scientists in gastrointestinal cancers

  This study is all about training new scientists to better understand and find ways to treat GI cancers, like those affecting the stomach and pancreas, so they can help improve care for patients like you.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10769254

• Improving access to surgery for African-Americans with gastrointestinal cancers in the Deep South

  This study is looking to improve surgical care for African-Americans with gastrointestinal cancers in Alabama and Mississippi by finding out what differences exist in treatment compared to white patients, so we can make sure everyone gets the best care possible.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10767175

Related topics

Quick answers

How many Gastrointestinal Cancers clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (7 trials), China (4 trials), Australia (1 trial), Belgium (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →