Understanding and Improving Chemoradiation Response in Esophagogastric and Pancreatic Cancer
Official title: High Resolution Dissection of Response Mechanisms to Chemoradiation in Gastrointestinal Cancers
Funded at Massachusetts General Hospital · NIH-11263056 · Data updated 2026-11-12
This grant aims to learn why esophagogastric and pancreatic cancers resist standard chemoradiation and to use that knowledge to guide better, biomarker-driven treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 4, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,652,508 |
| NIH project number | 1P01CA295486-01A1 |
| Project ID | NIH-11263056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with non-metastatic esophagogastric adenocarcinoma or pancreatic ductal adenocarcinoma undergoing neoadjuvant chemoradiation and surgery.
✕Less likely to help
Patients not receiving neoadjuvant chemoradiation or those not undergoing surgery may not directly benefit.
What this research studies
Researchers at Massachusetts General Hospital will study tumor samples from patients with esophagogastric and pancreatic cancers treated with chemoradiation and surgery. They will examine molecular and immunologic changes at high resolution to identify why some tumors don’t respond well. The project uses existing trial samples and builds a set of interconnected studies and core facilities to link biology with potential new trials. The goal is to pave the way for personalized, biomarker-informed approaches that improve local control and outcomes.
Why it matters
Potential benefit: If successful, the work could lead to more effective, tailored treatment plans for these difficult cancers.
How similar studies have gone: Prior phase II trials and biomarker studies suggest that understanding resistance mechanisms can inform better clinical strategies.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Klempner, Samuel J — Massachusetts General Hospital
- Study coordinator: Klempner, Samuel J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.