Condition

ER Positive Breast Cancer clinical trials and research

• 11Clinical trials
• 2NIH research projects
• 28Countries

Newest ER Positive Breast Cancer clinical trials

All recruiting trials (11)

• Support tool for women with HR+ breast cancer on long-term endocrine therapy

  This study tests a SHIELD web- and app-based portal to help women with hormone receptor–positive breast cancer manage symptoms while on long-term endocrine treatment.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07482384

• Palazestrant plus ribociclib as first-line treatment for ER+/HER2- advanced breast cancer

  This trial will test whether using palazestrant instead of letrozole, both given with ribociclib, helps adults with ER+/HER2- advanced breast cancer who have not had prior systemic treatment for their advanced disease.

  Recruiting at 198 sites Phase 3 Olema Pharmaceuticals, Inc. · Hot Springs, Arkansas and 199 other locations · NCT07085767

• Combination treatment for advanced ER-positive breast cancer with ESR1 mutations

  This study is testing if a new combination of two drugs can help people with advanced ER-positive breast cancer that has specific mutations live longer and keep their cancer under control.

  Recruiting at 81 sites Phase 3 MedSIR · Innsbruck and 103 other locations · NCT06382948

• Datopotamab deruxtecan for treating breast cancer that has spread to the brain

  This study is testing a new drug called datopotamab deruxtecan to see if it can help people with HER2-negative breast cancer that has spread to the brain.

  Recruiting at 3 sites Phase 2 Dana-Farber Cancer Institute · Miami, Florida and 2 other locations · NCT06176261

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Combination therapy for premenopausal women with advanced ER positive breast cancer

  This study is testing different combinations of medications to see if they can help premenopausal women with advanced breast cancer that hasn't improved with previous treatments.

  Recruiting Phase 2 National Taiwan University Hospital · Taipei · NCT05720260

• Using elacestrant to treat ER+/HER2- breast cancer patients with ctDNA relapse

  This study is testing if a new drug called elacestrant can help women with ER-positive, HER2-negative breast cancer who have had a relapse, compared to their usual treatment.

  Recruiting at 113 sites Phase 3 European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht and 112 other locations · NCT05512364

• Examining the immune environment in different types of breast cancer

  This study looks at tissue samples from women with different types of breast cancer to see how the immune environment affects treatment responses.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT05396612

• Combination treatment for advanced breast cancer

  This study is testing if a new combination of two drugs can help women with advanced breast cancer who haven't responded to previous treatments.

  Recruiting Phase 2 The Methodist Hospital Research Institute · Houston, Texas · NCT05305924

• Pre-operative treatment for HER2-positive, ER-positive breast cancer

  This study is testing if a new combination of treatments can help women with HER2-positive, ER-positive breast cancer before they have surgery.

  Recruiting at 4 sites Phase 2 Hoosier Cancer Research Network · Chicago, Illinois and 3 other locations · NCT04886531

• Identifying resistance to CDK4/6 inhibitors in breast cancer

  This study is trying to find out why some women with a specific type of advanced breast cancer don't respond to a common treatment that includes a CDK4/6 inhibitor and an aromatase inhibitor by collecting and analyzing their blood and tissue samples during treatment.

  Recruiting Fondazione Sandro Pitigliani · Prato, Tuscany · NCT04660435

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting the RB tumor suppressor to improve treatment for ER-positive breast cancer

  This study is looking at how a specific pathway in our cells, called the RB tumor suppressor pathway, influences the treatment of estrogen receptor-positive breast cancer, with the goal of finding better ways to help patients respond to common therapies and overcome challenges when tumors stop responding to treatment.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11010047

• Targeting the RB tumor suppressor in breast cancer treatment

  This study is looking at how changes in a specific cancer-fighting pathway affect the treatment of estrogen receptor-positive metastatic breast cancer, with the goal of finding better ways to overcome resistance to common therapies and improve outcomes for patients like you.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-10798148

Related topics

Quick answers

How many ER Positive Breast Cancer clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (7 trials), Italy (4 trials), France (3 trials), Germany (3 trials), Greece (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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