Condition

Early Breast Cancer clinical trials and research

• 16Clinical trials
• 4NIH research projects
• 16Countries

Newest Early Breast Cancer clinical trials

All recruiting trials (16)

• Giredestrant in ER-positive, HER2-negative early breast cancer: who tolerates it and sticks with treatment

  This study tests how well people with ER-positive, HER2-negative early breast cancer can tolerate and stay on giredestrant, and how they feel during treatment.

  Recruiting Phase 3 Hoffmann-La Roche · Québec, Quebec · NCT07827573

• Skipping sentinel lymph node biopsy for older women with luminal A early breast cancer

  This trial tests whether women over 59 with early luminal A, node‑negative breast cancer can safely skip sentinel lymph node biopsy and have breast surgery guided by imaging instead.

  Recruiting N.N. Petrov National Medical Research Center of Oncology · Saint Petersburg, Russian Federation · NCT07579286

• Giredestrant after aromatase inhibitor intolerance in early ER+/HER2- breast cancer

  This study tests switching to giredestrant for postmenopausal women with ER+/HER2- early breast cancer who had AI intolerance, to see if it’s tolerable and can improve patient-reported outcomes.

  Recruiting at 8 sites Phase 3 Genentech, Inc. · Fountain Valley, California and 7 other locations · NCT07541079

• Adherence to Cell Cycle Inhibitors with Endocrine Therapy in Localized High-Risk ER+ Breast Cancer

  This study checks how well patients with localized ER+ breast cancer stick to a combined endocrine therapy and CDK4/6 inhibitor after surgery.

  Recruiting University Hospital, Grenoble · Grenoble · NCT07443774

• Managing chemotherapy side effects with a smartphone symptom app plus telenursing

  This trial tests whether a smartphone symptom-reporting app combined with a standardized telenursing program helps adults starting first-cycle chemotherapy for gastric, lung, breast, or colon cancer manage treatment side effects.

  Recruiting at 4 sites Ulsan University Hospital · Busan and 4 other locations · NCT07405931

• MRI-guided early surgery and reduced chemotherapy for stage II–III triple-negative breast cancer

  This trial will try using MRI to decide whether adults with stage II–III triple-negative breast cancer who are receiving a pembrolizumab-containing neoadjuvant regimen can have earlier surgery and less chemotherapy.

  Recruiting at 2 sites Phase 2 Tel-Aviv Sourasky Medical Center · Tel Aviv and 1 other locations · NCT07327021

• Ovarian suppression after ZOLADEX 10.8 mg in premenopausal women with HR+ breast cancer

  This study tests how well ZOLADEX 10.8 mg can suppress ovaries in premenopausal women with HR+ breast cancer.

  Recruiting at 26 sites Phase 1 TerSera Therapeutics LLC · Hot Springs, Arkansas and 25 other locations · NCT07310420

• HandX-assisted endoscopic nipple-sparing mastectomy (ATHENA I)

  This study tests whether a handheld robotic device called HandX can help surgeons safely perform a minimally invasive nipple-sparing mastectomy with immediate implant reconstruction for women having therapeutic or risk-reducing mastectomy.

  Recruiting Mediterraneo Hospital · Glyfada, Attica · NCT07292246

• Atlas of cell organelles and protein patterns in breast cancer subtypes

  This project will collect tumor and blood samples from people with early or newly metastatic breast cancer to test how much fat accumulates in tiny cell structures (lipid droplets) and to map protein patterns across tumor subtypes.

  Recruiting Institut Claudius Regaud · Toulouse · NCT07233928

• Personalized chemo decisions for young HR+/HER2- breast cancer patients

  This trial tests whether using a genomic test can safely spare some premenopausal patients from chemotherapy in favor of endocrine therapy alone.

  Recruiting at 23 sites Phase 3 Unicancer · Brussels and 104 other locations · NCT07106632

• Mediterranean diet and socioeconomic differences in early breast cancer

  This project will test whether following a Mediterranean diet can improve the gut microbiome, quality of life, and treatment outcomes for people with early breast cancer receiving neoadjuvant or adjuvant chemotherapy, especially those with socioeconomic challenges.

  Recruiting at 3 sites Phase 2 Esbjerg Hospital - University Hospital of Southern Denmark · Sønderborg, Southern Denmark and 2 other locations · NCT07007169

• Hypofractionated radiotherapy with a tumor bed boost for early breast cancer

  This study is testing a new type of radiation treatment for women with early breast cancer to see if it can better control the disease while shortening the time they need treatment.

  Recruiting National Taiwan University Hospital · Taipei, Taiwan and 1 other locations · NCT06984250

• Impact of diet and exercise on early breast cancer treatment

  This study is testing if adding diet and exercise to standard breast cancer treatment can help improve health and treatment outcomes for women with early-stage breast cancer.

  Recruiting University of Eastern Piedmont · Novara, Novara · NCT06928701

• How well patients stick to aromatase inhibitor treatment, with or without abemaciclib, for early HR+/HER2- breast cancer

  This study tests whether people with early HR+/HER2- breast cancer stick to aromatase inhibitor treatment more or less when they also take abemaciclib.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT06650423

• Evaluating dalpiciclib with endocrine therapy for early breast cancer treatment

  This study is testing if adding dalpiciclib to hormone therapy can help women with early breast cancer that is hormone receptor-positive and HER2-negative feel better and stay cancer-free.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06341894

• Comparing Proton and Photon Radiation Therapy for Early Breast Cancer

  This study is testing whether proton radiation therapy is better than standard photon radiation therapy for early breast cancer patients by looking at its effects on heart health over 10 years.

  Recruiting at 7 sites Danish Breast Cancer Cooperative Group · Aalborg and 7 other locations · NCT04291378

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how dormant breast cancer cells wake up and cause relapse

  A research team will look at how dormant cancer cells hide and later cause local or distant breast cancer relapse, with a goal to identify ways to prevent or treat it.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11335049

• B7-H3 Targeted Ultrasound Imaging for Early and Metastatic Breast Cancer

  A new ultrasound imaging system using B7-H3 targeting aims to improve early detection and spread of breast cancer in women, especially those with dense breast tissue.

  NIH research Stanford University · Stanford, United States · NIH-11311280

• A new ultrasound imaging system for early detection of breast cancer

  This study is testing a new ultrasound method that uses special bubbles to help find breast cancer earlier and more accurately, especially for women with dense breast tissue, making it easier for doctors to diagnose and treat.

  NIH research Stanford University · Stanford, United States · NIH-11093921

• Combining blood tests and MRI to predict treatment response in early breast cancer

  This study is looking at how using blood tests to check for cancer DNA along with MRI scans can help doctors see how well early breast cancer patients are responding to their chemotherapy before surgery, so they can make better treatment decisions and improve outcomes for everyone involved.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10983795

Related topics

Quick answers

How many Early Breast Cancer clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in France (3 trials), Denmark (2 trials), United States (2 trials), Greece (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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