B7-H3 Targeted Ultrasound Imaging for Early and Metastatic Breast Cancer
Official title: B7-H3 Targeted Ultrasound Molecular Imaging System for Early Breast Cancer and Metastatic Detection
Funded at Stanford University · NIH-11311280 · Data updated 2026-11-12
A new ultrasound imaging system using B7-H3 targeting aims to improve early detection and spread of breast cancer in women, especially those with dense breast tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $568,129 |
| NIH project number | 5R01EB031799-04 |
| Project ID | NIH-11311280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women undergoing breast imaging who have radiographically dense breasts and are at risk for breast cancer.
✕Less likely to help
Patients with non-breast cancers or those not undergoing ultrasound imaging for breast concerns may not benefit.
What this research studies
This project at Stanford plans to create a real-time ultrasound imaging platform that uses targeted microbubbles to highlight breast tumors. The approach focuses on a specific protein, B7-H3, to improve sensitivity and specificity over standard ultrasound. If successful, the technology could be integrated into routine breast imaging clinics to help identify cancers earlier and distinguish benign from malignant lesions.
Why it matters
Potential benefit: If successful, patients could benefit from earlier and more accurate breast cancer detection using a noninvasive imaging method.
How similar studies have gone: Previous ultrasound molecular imaging work shows promise, but this project tests a specific B7-H3–targeted approach in breast cancer.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Dahl, Jeremy — Stanford University
- Study coordinator: Dahl, Jeremy
Related research
Other NIH-funded projects on the same topics.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.