Predicting challenges in thyroid surgery
Official title: Nomogram for Predicting Difficult Transoral and Submental Thyroidectomy
Run by Shanghai 6th People's Hospital · NCT06671184 · Data updated 2026-11-12
This study is trying to find out which factors can help doctors predict how challenging thyroid surgery will be for patients with thyroid cancer so they can plan better and keep patients safe.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Shanghai 6th People's Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT06671184 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with differentiated thyroid cancer, with tumors not exceeding 4 cm and no signs of lymph node involvement or metastasis.
✕Probably not a fit
Patients with prior neck surgeries, significant neck restrictions, or evidence of extrathyroidal invasion may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify preoperative factors that indicate the difficulty of transoral and submental thyroidectomy (TOaST) for patients with differentiated thyroid cancer. By analyzing clinicopathological factors, the researchers intend to develop a predictive model that can help surgeons anticipate surgical challenges. The study focuses on understanding the complexities involved in endoscopic thyroid surgery, which is gaining popularity due to its cosmetic advantages. The findings could enhance surgical planning and patient safety by minimizing complications associated with difficult surgeries.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and reduce complications for patients undergoing thyroid surgery.
How similar studies have gone: While there is limited research specifically on TOaST, studies on surgical difficulty in open thyroid surgery have shown that preoperative factors can be predictive of surgical outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of differentiated thyroid cancer with a maximum diameter not exceeding 4 cm * Absence of suspicious lateral lymph nodes or distant metastases * Participants with high cosmetic expectations * Participants who underwent total thyroidectomy and central lymph node dissection. Exclusion Criteria: * Participants with fusion or fixation of lymph nodes in the neck * Participants with history of neck surgery or radiation * Participants with vocal fold fixation by preoperative fibrolaryngoscope * Participants with preoperative examination suggestive of extrathyroidal invasion * Participants with a significantly restricted neck
Where it's running
-
Shanghai Sixth People's Hospital
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Ling Zhan, Doctor — Shanghai 6th People's Hospital
- Study coordinator: Ling Zhan, Doctor
- Email: rebecca0428zhan@163.com
- Phone: 08615821120972
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.