Drug or treatment

Larotrectinib clinical trials

• 4Clinical trials
• 6Countries

Newest trials

All recruiting trials (4)

• Using Larotrectinib to Improve Radioactive Iodine Treatment in Thyroid Cancer

  This study is testing if adding a drug called larotrectinib to radioactive iodine treatment can help people with a specific type of thyroid cancer that has spread to the lungs feel better.

  Recruiting at 5 sites Phase 2 Children's Hospital of Philadelphia · San Francisco, California and 5 other locations · NCT05783323

• Using larotrectinib for advanced or recurrent solid tumors with NTRK gene fusion

  This study is testing how well larotrectinib works for adults and children with advanced or recurrent solid tumors caused by NTRK gene fusions.

  Recruiting Bayer · Multiple Locations · NCT04945330

• Treatment of advanced solid tumors with larotrectinib for NTRK gene amplification

  This study is testing if a new drug called larotrectinib can help people with advanced solid tumors that have a specific gene change called NTRK amplification.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT04879121

• Using Larotrectinib for Children with Newly Diagnosed High-Grade Glioma with NTRK Fusion

  This study is testing if a new drug called larotrectinib can help children with a specific type of brain cancer called high-grade glioma that has an NTRK fusion.

  Recruiting at 20 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 20 other locations · NCT04655404

Quick answers

How many clinical trials of Larotrectinib are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (3 trials), Japan (1 trial), Australia (1 trial), Canada (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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