Condition

Cutaneous Lupus Erythematosus (CLE) clinical trials and research

• 8Clinical trials
• 1New in 30 days
• 20Countries

Newest Cutaneous Lupus Erythematosus (CLE) clinical trials

All recruiting trials (8)

• Afimetoran in Adults With Cutaneous Lupus Erythematosus

  This study tests whether the oral medicine afimetoran helps skin lupus in adults who did not respond to antimalarials, by comparing it with a placebo over 24 weeks followed by all participants receiving the drug for 28 more weeks.

  Recruiting at 3 sites Phase 2/3 Beeline Medicines Corporation · San Diego, California and 2 other locations · NCT07881120

• Long-Term Extension of enpatoran for cutaneous lupus symptoms

  This extension study tests whether continuing enpatoran is safe and helpful for people with skin lupus who completed previous trials, for up to about two years.

  Recruiting Phase 3 EMD Serono · Troy, Michigan · NCT07840287

• Quinacrine for Cutaneous Lupus Erythematosus

  This study tests whether quinacrine can help adults with active cutaneous lupus erythematosus when compared to placebo.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07694336

• S-4321 in adults with autoimmune or immune-mediated diseases

  This study tests S-4321 in adults with autoimmune conditions to see if it is safe and tolerable and to gather early data on how the drug behaves in the body and its initial effects on disease markers.

  Recruiting at 2 sites Phase 1 Seismic Therapeutic AU Pty Ltd · Charlestown, New South Wales and 1 other locations · NCT07455578

• ICP-488 for Cutaneous Lupus Erythematosus: a 2nd phase study to test safety and efficacy

  This phase II study tests ICP-488 versus placebo in adults with cutaneous lupus erythematosus to see if it helps skin symptoms while checking safety.

  Recruiting at 10 sites Phase 2 Beijing InnoCare Pharma Tech Co., Ltd. · Hefei, Anhui and 26 other locations · NCT07440537

• Enpatoran for adults with skin lupus, with or without systemic disease

  This 24-week test will see if enpatoran tablets reduce active skin lesions in adults with cutaneous lupus, with or without systemic lupus.

  Recruiting at 74 sites Phase 3 EMD Serono · Los Angeles, California and 73 other locations · NCT07332481

• Lupus patient registry for better understanding and care

  This study is collecting information from adults with lupus to help improve understanding and care for the disease.

  Recruiting Lupus Foundation of America · Washington D.C., District of Columbia · NCT06927219

• Understanding the prevalence and severity of cutaneous lupus erythematosus

  This study is trying to understand how common and severe skin lupus is by collecting information from patients to help improve their treatment and quality of life.

  Recruiting at 2 sites University of Pennsylvania · Philadelphia, Pennsylvania and 1 other locations · NCT01510067

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Quick answers

How many Cutaneous Lupus Erythematosus (CLE) clinical trials are recruiting right now?

8, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (6 trials), Australia (2 trials), China (2 trials), Belgium (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 2, Phase 2/3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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