MMA Embolization for Migraine: Patient-Reported Outcomes from a Single Site
Official title: Enduring Migraine Benefit From Responsive Artery Coil Embolization - Observational (EMBRACE-OBS): A Single-Site Registry of Patient-Reported Outcomes Following Routine Clinical Care for Migraine
Run by Cortex Neurovascular · NCT07652034 · Data updated 2026-11-12
This registry tests whether adults with migraine who have or plan to have middle meningeal artery embolization notice changes in headaches and quality of life over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 64 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Cortex Neurovascular Industry-sponsored |
| Locations | 1 site (Tacoma, Washington) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | June 1, 2028 |
| Study ends | June 1, 2028 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT07652034 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 64 with a migraine diagnosis who have undergone or plan MMA embolization as part of routine care and can consent in English.
✕Probably not a fit
Patients who do not undergo MMA embolization or who have incomplete data may not contribute to outcome descriptions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
EMBRACE-OBS is a single-site registry that uses data already collected in routine care to describe how headache frequency, headache severity, and migraine-related quality of life change after MMA embolization. It does not change how patients are treated or followed. The study also documents medication use and any adverse events to understand the real-world safety and impact of the procedure. Follow-up relies on standard clinical visits and patient-reported measures such as headache diaries and validated questionnaires.
Why it matters
Potential benefit: If successful, the registry could clarify real-world outcomes and safety of MMA embolization for migraine, informing patients and clinicians.
How similar studies have gone: Other observational studies in similar real-world settings have provided useful insights into outcomes after MMA embolization for migraine, supporting the value of this registry.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 64 years * Diagnosis of migraine * Have undergone or plan to undergo middle meningeal artery (MMA) embolization as part of routine clinical care, independent of study participation * Able and willing to provide informed consent * Able to read and understand English sufficiently to complete informed consent and patient-reported outcome assessments Exclusion Criteria: * Age under 18 years * Pregnancy at the time of enrollment * Inability to provide informed consent * Inability to read and understand English sufficiently to complete informed consent and patient-reported outcome assessments * Insufficient clinical or patient-reported outcome data for the planned analyses
Where it's running
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Cortex Neurovascular / TRA Union
Tacoma, Washington, United States Recruiting
Study contacts
- Study coordinator: Dennis Wang, Principal Investigator, MD
- Email: dwang@cortexmgmt.com
- Phone: 253-284-0841
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Analyzing CGRP Levels in Migraine Patients by Age and Sex
This study looks at the levels of a substance linked to migraines in people with migraines and healthy individuals to see how age and sex might affect treatment responses.
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HEADS Registry: Headache, Ear, Auditory, Dizziness, and Sinus</n> Registry
This registry tests whether collecting online symptom reports from adults in the U.S. with sinus, vestibular, ear, or headache symptoms can help improve diagnosis and treatment.
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Bilateral middle meningeal artery embolization for refractory chronic migraine
This study will try blocking both middle meningeal arteries with Onyx in adults who have refractory bilateral chronic migraine to see if it is safe and lowers headaches.
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Real-world use of anti-CGRP medicines for preventing migraine
This project will follow people with episodic or chronic migraine who start anti-CGRP medicines to see if the treatments reduce migraine frequency and side effects over two years.
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New methods to test preventive migraine treatment
This trial will test how the active medicine, placebo injections, and the information given about them affect symptoms in adults with chronic migraine.
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Nordic comparison of CGRP antibody plus onabotulinumtoxinA (Botox) versus CGRP antibody alone for chronic migraine
This trial will test whether adding onabotulinumtoxinA (Botox) to a CGRP monoclonal antibody reduces monthly headache days in adults with chronic migraine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.