What Makes People with Chronic Migraine Susceptible to Suggestion and How It Relates to Placebo

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study looks at the link between suggestibility and placebo-related responses in chronic migraine patients who have not benefited from routine preventive therapies. It aims to identify biological and clinical markers that predict placebo sensitivity using non-interventional assessments. The study also considers connectomics and other biomarkers to understand underlying mechanisms. Healthy volunteers may be included for comparison to establish baseline levels of suggestibility and biomarkers. Findings could help tailor future therapies by clarifying who is more likely to experience placebo-related benefits.

Why it matters

Who can join: the full rules

Inclusion Criteria for Non-Responsive Chronic Migraine subjects:

* adults aged ≥ 18 years and ≤ 75 years;
* diagnosis of non-responsive chronic migraine (NRCM) according to ICHD-3 beta criteria;
* presence of at least 8 migraine days per month associated with disability (MIDAS ≥ 11), and insufficient response after 6 weeks or inability to tolerate at least three previously prescribed migraine preventive agents, i.e., resistance to standard therapy for at least 6 weeks;
* signed informed consent.

Inclusion Criteria for healthy subjects are:

* adults aged ≥ 18 years and not older than 75 years;
* absence of a diagnosis of NRCM according to ICHD3beta or other relevant -neurological disorders as assessed during the medical history taken at the headache center;
* signed informed consent.

Exclusion Criteria:

* older than 75 years;
* children
* pregnant or breastfeeding women;
* history of alcohol or substance abuse;
* affected by concomitant neurological, cardiovascular, or cerebrovascular diseases;
* liver disease or kidney disease;
* psychiatric disorders (psychosis, major depression, bipolar disorder).
* diagnosis or history of migraine (for healthy subjects).

Where it's running

• Renato Dulbecco University Hospital
  Catanzaro, Catanzaro, Italy Recruiting

Study contacts

• Study coordinator: Domenico Bosco, Medical Doctor
• Email: nico_bosco@libero.it
• Phone: 0961/883021

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Analyzing CGRP Levels in Migraine Patients by Age and Sex

  This study looks at the levels of a substance linked to migraines in people with migraines and healthy individuals to see how age and sex might affect treatment responses.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT06674772

• MySalvia System for Resistant Migraine: a minimally invasive implant to prevent migraines

  This study tests whether the MySalvia System, a small implant that stimulates nerves, can prevent migraines in adults with resistant or chronic migraine.

  Recruiting at 3 sites Salvia BioElectronics · Newnan, Georgia and 2 other locations · NCT07719608

• MMA Embolization for Migraine: Patient-Reported Outcomes from a Single Site

  This registry tests whether adults with migraine who have or plan to have middle meningeal artery embolization notice changes in headaches and quality of life over time.

  Recruiting Cortex Neurovascular · Tacoma, Washington · NCT07652034

• Ultrasound-Guided Nerve Block High-Voltage PRF for Chronic Migraine

  This study tests whether a higher-voltage pulsed radiofrequency treatment applied to the sphenopalatine ganglion under ultrasound guidance can help adults with chronic migraine who haven’t had enough relief from other preventives.

  Recruiting at 2 sites Minia University · Minya and 1 other locations · NCT07500558

• Myofascial trigger point steroid injection versus greater occipital nerve block for chronic migraine

  This trial will test whether steroid injections into myofascial trigger points work as well as greater occipital nerve block for adults (18–65) with chronic migraine who still have moderate pain despite treatment.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347067

• Bilateral middle meningeal artery embolization for refractory chronic migraine

  This study will try blocking both middle meningeal arteries with Onyx in adults who have refractory bilateral chronic migraine to see if it is safe and lowers headaches.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07223008

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.