Nerve branches to the vastus medialis added to genicular nerve treatment for chronic knee pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational cohort study enrolling adults aged 45-80 with clinically and radiologically confirmed knee osteoarthritis and chronic knee pain (≥3 months) who have not fully responded to conservative care. Participants will receive either conventional genicular nerve radiofrequency alone or with additional pulsed radiofrequency targeting the distal sensory branches of the nerve to vastus medialis, and will be followed in routine clinical practice. Outcomes include pain measured by the Visual Analog Scale and function via the WOMAC score, assessed at baseline, 1 month, and 3 months after the procedure. The study aims to compare outcomes between the two treatment approaches and monitor safety events related to the procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age between 45 and 80 years Clinical and radiological diagnosis of knee osteoarthritis Kellgren-Lawrence grade II-IV knee osteoarthritis Chronic knee pain lasting at least 3 months Insufficient response to conservative treatments such as NSAIDs, physical therapy, or exercise programs Baseline Visual Analog Scale pain score ≥5 No coagulation disorder or active infection that would contraindicate the procedure Written informed consent provided by the participant

Exclusion Criteria:

Knee pain primarily caused by conditions other than osteoarthritis, including inflammatory arthritis, septic arthritis, tumor-related causes, or infectious causes Previous total knee arthroplasty or knee prosthesis surgery in the affected knee Radiofrequency or neurolytic procedure around the affected knee within the last 6 months Severe knee instability, advanced deformity, or history of acute trauma Active infection, skin lesion, or ulceration at the procedure site Uncontrolled systemic disease such as advanced heart failure or uncontrolled diabetes Bleeding diathesis or inability to discontinue anticoagulant therapy for an appropriate duration Pregnancy or lactation Cognitive impairment, inability to cooperate, or inability to comply with follow-up visits

Where it's running

• Ayse Betul Acar
  Ankara, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.