Condition

Chronic Musculoskeletal Pain clinical trials and research

• 12Clinical trials
• 19NIH research projects
• 6Countries

Newest Chronic Musculoskeletal Pain clinical trials

All recruiting trials (12)

• vEAET-H: a virtual group emotional therapy for chronic pain patients using medical cannabis in Israel

  This study tests a Hebrew, virtual, group-based emotional therapy to see if it can help reduce pain and improve emotional well-being in Israeli adults with chronic musculoskeletal pain who use medical cannabis.

  Recruiting Reuth Rehabilitation Hospital · Tel Aviv · NCT07732062

• Steroid injections into myofascial trigger points versus joint injections for shoulder osteoarthritis

  This study will test whether steroid injections into muscle trigger points work as well as steroid injections into the shoulder joint for adults with shoulder osteoarthritis and ongoing shoulder pain.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347054

• Trigger-point steroid injections versus hip joint steroid injections for hip osteoarthritis

  This test compares steroid injections into myofascial trigger points versus injections into the hip joint to see which reduces pain and improves function in people aged 45 and older with hip osteoarthritis.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347041

• Glucocorticoid injections into myofascial trigger points to treat knee osteoarthritis.

  This study will test whether injecting corticosteroid into myofascial trigger points reduces pain and improves function for adults 45 and older with knee osteoarthritis.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347028

• Stepped-care music listening and imagery for pain relief in Veterans with chronic musculoskeletal pain

  This trial tests whether a stepped telehealth program of music listening followed by music imagery can help Veterans with chronic musculoskeletal pain reduce their pain and related distress.

  Recruiting Henry M. Jackson Foundation for the Advancement of Military Medicine · Indianapolis, Indiana · NCT07217821

• Comparing two single-session online pain trainings with an eight-week mindfulness program for adults with chronic musculoskeletal pain

  This project tests whether two different single-session, 2-hour online pain-management trainings work as well as an eight-week mindfulness program for adults with chronic musculoskeletal pain.

  Recruiting Florida State University · Tallahassee, Florida · NCT07193095

• Single-session CBT, PRT, or EAET for chronic musculoskeletal pain

  This trial tests whether a single 90-minute session of CBT, Pain Reprocessing Therapy (PRT), or Emotion Awareness and Expression Therapy (EAET) reduces pain and improves mood for adults in the U.S. with chronic musculoskeletal pain compared with no treatment.

  Recruiting at 2 sites Wayne State University · Chicago, Illinois and 1 other locations · NCT07008105

• Communication-focused pain neuroscience education for chronic musculoskeletal pain

  This will test whether teaching physiotherapists extra communication skills while they deliver pain neuroscience education helps adults with chronic back, neck, shoulder, or knee pain more than the same education without communication training or usual physiotherapy.

  Recruiting University of Thessaly · Lamia, Central Greece · NCT07001449

• Effects of Theta Burst Stimulation on Pain and Cognition in Older Adults

  This study is testing whether a new brain stimulation technique can help older adults with chronic pain feel better and think more clearly.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT06709963

• Community exercise program for older adults with chronic pain

  This study is testing a community exercise program for older adults with chronic pain to see if fun activities like Tai Chi and Aquarobics can help them feel better and move more easily.

  Recruiting University of Limerick · Limerick · NCT06535633

• Group psychological treatments via video for older veterans with chronic pain

  This study is testing three different video-based therapy options to see which one helps older veterans with chronic pain feel better.

  Recruiting at 2 sites VA Office of Research and Development · West Los Angeles, California and 1 other locations · NCT06004804

• Improving physical function in veterans with COPD and chronic pain through walking and Tai Chi

  This study is testing if a program that combines walking and Tai Chi can help veterans with COPD and chronic pain improve their physical abilities and overall well-being.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT05701982

NIH-funded research (19)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biopsychosocial factors in pediatric chronic musculoskeletal pain

  A study at Cincinnati Children’s Hospital will look at how biological, psychological, and social factors contribute to chronic muscle and joint pain in young people to find better ways to help them.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11419876

• Neurobiological and psychosocial factors that may turn acute teen pain into chronic pain

  A study following teenagers with acute musculoskeletal pain to understand why some develop chronic pain and how biology and psychology interact to shape their outcomes.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11395328

• Tech-guided walking plus Tai Chi to improve function for veterans with COPD and chronic pain

  This program helps veterans with COPD and long-term muscle or joint pain use a web-based step program together with Tai Chi to move more and feel stronger.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11381365

• Resilience Coaching for Teens with Long-Lasting Muscle and Bone Pain

  This project offers resilience coaching to help teenagers manage ongoing muscle and bone pain and improve their well-being.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11363175

• GET SMART: Tailored graded exposure for kids with chronic musculoskeletal pain

  A multi-site trial tests a stepwise, personalized exposure-based therapy for children with long-standing musculoskeletal pain and their families.

  NIH research Stanford University · Stanford, United States · NIH-11363104

• Online yoga vs. acceptance-based therapy for chronic musculoskeletal pain in veterans

  A large, well-designed study will compare online yoga to acceptance and commitment therapy to help veterans manage chronic musculoskeletal pain.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11309136

• Why teens' muscle and joint pain can become long-term

  This project looks at brain changes and social-emotional factors in teens with recent muscle or joint pain to find who is likely to develop long-lasting pain.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11159569

• A Digital Program for Young People with Chronic Muscle and Joint Pain

  This project is creating a new online program to help young people and their parents manage ongoing muscle and joint pain.

  NIH research Stanford University · Stanford, United States · NIH-11120991

• Helping adolescents with chronic pain build resilience

  This study is looking at a program called PRISM that helps teenagers with ongoing pain by teaching them skills to handle stress and build resilience, so they can feel better both physically and emotionally while connecting with others who understand what they're going through.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11098675

• How sleep affects pain in teens after surgery

  This study is looking at how sleep and other factors affect pain in teens after surgery, with the hope of finding ways to help them avoid long-lasting pain.

  NIH research Stanford University · Stanford, United States · NIH-11061410

• Exploring the effects of medical marijuana on chronic pain in older adults

  This study is looking at how medical marijuana can help older adults with ongoing pain in their muscles and joints, and it wants to find out which people might get the most relief from it by looking at their health and personal backgrounds over three months.

  NIH research University of Florida · Gainesville, United States · NIH-11056415

• Understanding how sex differences affect chronic pain after trauma

  This study is looking at how men and women feel and deal with long-lasting pain after an injury, focusing on tiny molecules in the body that might affect this pain differently for each sex, with the hope of finding better treatments for everyone.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11042705

• Comparing online yoga and therapy for chronic pain relief

  This study is looking at whether online yoga can help reduce chronic pain just as well as a type of therapy called Acceptance and Commitment Therapy (ACT), especially for veterans who might not have easy access to regular healthcare.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11040817

• Combining physical therapy with mindfulness for chronic pain patients on opioids

  This study is looking at how combining mindfulness practices with physical therapy can help people with chronic pain who are using long-term opioids, making it easier for them to manage their pain and reduce their reliance on medication in a friendly and supportive setting.

  NIH research University of Utah · Salt Lake City, United States · NIH-10989921

• Understanding how resilience and physical activity affect chronic pain in adolescents

  This study is looking at how being mentally strong and active can help teenagers with ongoing pain in their muscles and joints, and it involves 60 teens sharing their experiences and wearing devices to track their activity levels.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10909983

• Understanding why some adolescents develop chronic pain from acute musculoskeletal issues

  This study is looking at why some teenagers with short-term pain end up with long-lasting pain, and it aims to find ways to help prevent that from happening by understanding both their brain activity and emotional well-being.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10888368

• Developing a digital treatment for young people with chronic pain

  This study is testing a new online program called iGET Living to help teenagers with ongoing pain in their muscles and joints by encouraging them to gradually get back to activities they might have been avoiding, and it’s designed to be easy for both the teens and their parents to use.

  NIH research Stanford University · Stanford, United States · NIH-10874721

• Preventing chronic pain in older adults after acute musculoskeletal injuries

  This study is all about helping older adults who have sudden pain from injuries, like falls, by teaching them how to make better choices about their treatment, so they can avoid long-lasting pain and feel more in control of their recovery.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10539315

• Understanding why some young people develop chronic musculoskeletal pain

  This study is looking at why some young people aged 12 to 20 develop long-lasting pain after having short-term pain, and it aims to find out how things like emotions and behaviors play a role, so we can help those who might be at risk.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10455657

Related topics

Quick answers

How many Chronic Musculoskeletal Pain clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (5 trials), China (3 trials), Hong Kong (1 trial), Ireland (1 trial), Greece (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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