Condition

Central Nervous System Lymphoma clinical trials and research

• 13Clinical trials
• 3NIH research projects
• 4Countries

Newest Central Nervous System Lymphoma clinical trials

All recruiting trials (13)

• Thiotepa with pirtobrutinib and sintilimab for frail or relapsed/refractory CNS lymphoma

  This treatment combines thiotepa with pirtobrutinib and sintilimab for adults who are frail or whose primary or secondary central nervous system lymphoma has relapsed or not responded to prior therapy.

  Recruiting Phase 2 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT07416890

• Epcoritamab plus ibrutinib for central nervous system lymphoma

  This trial tests whether combining epcoritamab and ibrutinib is safe and tolerable for adults with relapsed or refractory primary or secondary central nervous system lymphoma.

  Recruiting at 8 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT07082868

• Using loncastuximab tesirine and rituximab after targeted radiation for brain lymphomas

  This study is testing if a combination of two medications, loncastuximab tesirine and rituximab, can help adults with certain types of brain lymphomas after they receive targeted radiation treatment.

  Recruiting at 3 sites Phase 1 University of Utah · Philadelphia, Pennsylvania and 2 other locations · NCT06607549

• CAR T Cell Therapy for Resistant B-cell Cancers

  This study is testing a new CAR T cell therapy to see if it can safely help people with tough-to-treat B-cell cancers like leukemia and lymphoma.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06213636

• Long-term follow-up for patients treated with zamtocabtagene autoleucel

  This study follows patients who have received a specific CAR T-cell therapy for non-Hodgkin lymphoma to see how they do over time and if there are any long-term side effects.

  Recruiting at 10 sites Miltenyi Biomedicine GmbH · Gilbert, Arizona and 10 other locations · NCT06116110

• Combination treatment for relapse refractory central nervous system lymphoma

  This study is testing a new combination of three medications to see if it can help people with hard-to-treat central nervous system lymphoma feel better.

  Recruiting Phase 1/2 Huashan Hospital · Hefei, Anhui and 4 other locations · NCT05698147

• Treatment of primary central nervous system lymphoma using modified T cells delivered into the brain

  This study is testing if giving special immune cells directly into the brain can help people with primary central nervous system lymphoma fight their cancer.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05625594

• Lenalidomide maintenance for patients with primary CNS lymphoma

  This study is testing if lenalidomide can help patients with primary CNS lymphoma stay in remission after their initial treatment.

  Recruiting Phase 2 Seoul National University Bundang Hospital · Seongnam-si, Please Select · NCT05260619

• Combining orelabrutinib and pemetrexed for treating relapsed central nervous system lymphoma

  This study is testing if combining orelabrutinib with pemetrexed can help people with relapsed central nervous system lymphoma feel better and improve their treatment outcomes.

  Recruiting Phase 2 Henan Cancer Hospital · Zhengzhou, Henan · NCT05209620

• Assessing cognitive effects of whole brain radiation therapy in blood cancer patients

  This study is testing how whole brain radiation therapy affects thinking and memory in blood cancer patients, while also looking at quality of life and brain changes over time.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05011045

• CAR-T cell therapy for relapsed or refractory DLBCL

  This study is testing a new CAR-T cell therapy to see if it can help people with tough-to-treat diffuse large B cell lymphoma feel better after other treatments haven’t worked.

  Recruiting at 30 sites Phase 2 Miltenyi Biomedicine GmbH · Birmingham, Alabama and 31 other locations · NCT04792489

• CAR-T cell therapy for patients with relapsed B cell cancers

  This study is testing a new CAR-T cell therapy for adults with relapsed B cell cancers to see how well it works and if different manufacturing methods make a difference in treatment outcomes.

  Recruiting Phase 1/2 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT04186520

• Long-term follow-up of patients receiving CAR-T cell therapy

  This study is tracking patients who have received CAR-T cell therapy for up to 15 years to see how well the treatment works over time and if there are any long-term health issues.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT03375619

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Direct-to-CNS CAR T cells for PCNSL treatment

  A patient-focused look at using CD19 CAR T cells delivered directly into the brain to treat primary CNS lymphoma.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11399143

• CD19 CAR T cells given into the brain fluid for primary CNS lymphoma

  This work uses CD19-directed CAR T cells delivered into the fluid around the brain to treat people with primary central nervous system lymphoma.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11191591

• Using targeted immune cells to treat brain lymphoma

  This study is testing a new way to treat primary central nervous system lymphoma by delivering special immune cells directly into the brain to help them better fight the cancer, and it's designed for patients looking for more effective options than what's currently available.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-10912468

Related topics

Quick answers

How many Central Nervous System Lymphoma clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), China (4 trials), Canada (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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